Twenty-five years ago, we reported that agonist anti-CD137 monoclonal antibodies
eradicated transplanted mouse tumors because of enhanced CD8+ T-cell antitumor …

Prosurvival tumor necrosis factor receptor (TNFR) superfamily (TNFRSF) members on T
cells, including 4-1BB, CD27, GITR, and OX40, support T cell accumulation during clonal …

Presentation of exogenous antigens on MHC-I molecules, termed cross-presentation, is
essential for cytotoxic CD8+ T cell responses. In mice, dendritic cells (DCs) that arise from …

Abstract Type I Interferons (IFN-I) mediate numerous immune interactions during viral
infections, from the establishment of an antiviral state to invoking and regulating innate and …

Cognate interaction between CD4+ effector memory T (T EM) cells and dendritic cells (DCs)
induces innate inflammatory cytokine production, resulting in detrimental autoimmune …

MicroRNAs (miRNAs) are involved in lymphoma progression by regulating the tumor
microenvironment. Serum miR130b is overexpressed in diffuse large B-cell lymphoma …

The generation of an efficacious vaccine that elicits protective CD4+ T cell-mediated
immunity has been elusive. The lack of a vaccine against the Leishmania parasite is …

Antigen presentation is a key feature of classical dendritic cells (cDCs). Numerous studies
have also reported in mouse that, upon inflammation, monocytes enter tissues and …

Human mononuclear phagocytes comprise specialized subsets of dendritic cells (DCs) and
monocytes, but how these subsets individually regulate expression of the molecular signals …

Acute respiratory disease caused by influenza viruses is imperfectly mitigated by annual
vaccination to select strains. Development of vaccines that elicit lung-resident memory CD8+ …