Good animal welfare is linked to the quality of research data derived from laboratory
animals, their validity as models of human disease, the number of animals required to reach …

Background Temporal lobe epilepsy is a common and frequently intractable seizure
disorder. Its pathogenesis is thought to involve large-scale alterations to the expression of …

Epilepsy is a brain disease characterized by abnormal electrical activity causing seizures or
unusual behaviour, sensations and sometimes loss of awareness. It carries neurological …

Ensuring that laboratory rodent pain is well managed underpins the ethical acceptability of
working with these animals in research. Appropriate treatment of pain in laboratory rodents …

Many experimental approaches require housing rodents in individual cages, including in
epilepsy research. However, rats and mice are social animals; and individual housing …

Behaviorally and pathologically relevant cortico-thalamo-cortical oscillations are driven by
diverse interacting cell-intrinsic and synaptic processes. However, the mechanism that gives …

Over the decades, various interventions have been developed and utilized to treat epilepsy.
However, the majority of epileptic patients are often first prescribed anti-epileptic drugs …

In most mouse models of disease, the outward manifestation of a disorder can be measured
easily, can be assessed with a trivial test such as hind limb clasping, or can even be …

A survey was conducted regarding zebrafish Danio rerio use for scientific research with a
focus on: anaesthesia and euthanasia; housing and husbandry; breeding and production; …

Seizures can emerge from multiple or large foci in temporal lobe epilepsy, complicating
focally targeted strategies such as surgical resection or the modulation of the activity of …