Background Cardiac autonomic neuropathy in type 2 dibetes mellitus (T2DM) patients is
frequent and associated with high cardiovascular mortality. Heart rate variability (HRV) is the …

Heart failure with preserved ejection fraction (HFpEF) is now the most common form of HF,
affecting over 3 million adults in the United States alone. HFpEF is a heterogenous …

This study tested the hypothesis that acute exposure to light during nighttime sleep
adversely affects next-morning glucose homeostasis and whether this effect occurs via …

Recent clinical trial data suggest a cardiorenal protective effect of sodium glucose
cotransporter 2 (SGLT2) inhibition. We demonstrate that chemical denervation in neurogenic …

Sarcopenia is an important public health problem, characterized by age-related loss of
muscle mass and muscle function. It is a precursor of physical frailty, mobility limitation, and …

The incidence and prevalence of hypertension is increasing worldwide, with approximately
1.13 billion of people currently affected by the disease, often in association with other …

Body fat mass increases when energy intake exceeds energy expenditure. In the long term,
a positive energy balance will result in obesity. The worldwide prevalence of obesity has …

Obesity is a growing global health concern, with a rapid increase being observed in morbid
obesity. Obesity is associated with an increased cardiovascular risk and earlier onset of …

Even in the presence of excess glucose, the proximal renal tubules continue to resorb more
glucose. Sodium glucose cotransporter 2 (SGLT2) inhibitors are drugs that control this …

Background: The sympathetic nervous system (SNS) regulates glucose metabolism in
various organs including the kidneys. The sodium glucose cotransporter 2 (SGLT2) …