Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine encoded within a
functionally polymorphic genetic locus. MIF was initially recognized as a cytokine generated …

Macrophages are the most numerous immune-cells present in the lung environment under
homoeostatic conditions and are ideally positioned to dictate the innate defence of the …

The role of macrophage migration inhibitory factor (MIF) in autoimmunity is underscored by
data showing that common functional polymorphisms in MIF are associated with disease …

Excessive inflammation drives the progression from sepsis to septic shock. Macrophage
migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict …

Introduction. Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory
cytokine with upstream regulatory roles in innate and adaptive immunity and is implicated in …

The application of tumor immunotherapy to glioblastoma (GBM) is limited by an
unprecedented degree of immune suppression due to factors that include high numbers of …

Spondyloarthritis (SpA), a type 3 immunity-mediated inflammatory arthritis, is a systemic
rheumatic disease that primarily affects the joints, spine, gut, skin, and eyes. Macrophage …

Mycobacterium tuberculosis (Mtb), the primary causative agent of human tuberculosis, has
killed more people than any other bacterial pathogen in human history and remains one of …

Tuberculosis (TB) is the leading killer among all infectious diseases worldwide despite
extensive use of the Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine. A safer …

Cancers harbor significant genetic heterogeneity and patterns of relapse following many
therapies are due to evolved resistance to treatment. While efforts have been made to …