Cross-talk between cancer stem cells and immune cells: potential therapeutic targets in the tumor immune microenvironment

B Wu, X Shi, M Jiang, H Liu - Molecular Cancer, 2023 - Springer
Ongoing research has revealed that the existence of cancer stem cells (CSCs) is one of the
biggest obstacles in the current cancer therapy. CSCs make an influential function in tumor …

Histone modifications in drug-resistant cancers: From a cancer stem cell and immune evasion perspective

ML Jin, KW Jeong - Experimental & Molecular Medicine, 2023 - nature.com
The development and immune evasion of cancer stem cells (CSCs) limit the efficacy of
currently available anticancer therapies. Recent studies have shown that epigenetic …

Exploring the dynamic interplay between cancer stem cells and the tumor microenvironment: implications for novel therapeutic strategies

YR Li, Y Fang, Z Lyu, Y Zhu, L Yang - Journal of Translational Medicine, 2023 - Springer
Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and
metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby …

Cancer stem cells: emerging key players in immune evasion of cancers

MML Lei, TKW Lee - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Cancer stem cells (CSCs) are subpopulations of undifferentiated cancer cells within the
tumor bulk that are responsible for tumor initiation, recurrence and therapeutic resistance …

Circulating tumor cells: from new biological insights to clinical practice

X Gu, S Wei, X Lv - Signal Transduction and Targeted Therapy, 2024 - nature.com
The primary reason for high mortality rates among cancer patients is metastasis, where
tumor cells migrate through the bloodstream from the original site to other parts of the body …

Immune evader cancer stem cells direct the perspective approaches to cancer immunotherapy

H Dianat-Moghadam, A Mahari, R Salahlou… - Stem Cell Research & …, 2022 - Springer
Exploration of tumor immunity leads to the development of immune checkpoint inhibitors and
cell-based immunotherapies which improve the clinical outcomes in several tumor types …

The cross talk between gastric cancer stem cells and the immune microenvironment: a tumor-promoting factor

J Becerril-Rico, E Alvarado-Ortiz… - Stem Cell Research & …, 2021 - Springer
Cross talk between cancer cells and the immune system is determinant for cancer
progression. Emerging evidence demonstrates that GC characteristics such as metastasis …

Obesity, dietary fats, and gastrointestinal cancer risk-potential mechanisms relating to lipid metabolism and inflammation

KAJ Mitchelson, F O'Connell, J O'Sullivan, HM Roche - Metabolites, 2024 - mdpi.com
Obesity is a major driving factor in the incidence, progression, and poor treatment response
in gastrointestinal cancers. Herein, we conducted a comprehensive analysis of the impact of …

MiR‐192‐5p/RB1/NF‐κBp65 signaling axis promotes IL‐10 secretion during gastric cancer EMT to induce Treg cell differentiation in the tumour microenvironment

J Song, Z Lin, Q Liu, S Huang, L Han… - Clinical and …, 2022 - Wiley Online Library
Abstract Background Regulatory T (Treg) cells are important components of the tumour
microenvironment (TME) that play roles in gastric cancer (GC) metastasis. Although tumour …

Gastric non-Helicobacter pylori urease-positive Staphylococcus epidermidis and Streptococcus salivarius isolated from humans have contrasting effects on H. pylori …

Z Shen, JA Dzink-Fox, Y Feng, S Muthupalani… - Msphere, 2022 - Am Soc Microbiol
In populations with similar prevalence of Helicobacter pylori infection, cancer risk can vary
dramatically. Changes in composition or structure of bacterial communities in the stomach …