As early as the 1920s, and subsequently in the 1959 Build and Blood Pressure Study (S1. 5-
1) of almost 5 million adults insured between 1934 and 1954, a strong direct relationship …

Background—Age-related dementia, most commonly caused by Alzheimer disease or
cerebrovascular factors (vascular dementia), is a major public health threat. Chronic arterial …

Importance There are currently no proven treatments to reduce the risk of mild cognitive
impairment and dementia. Objective To evaluate the effect of intensive blood pressure …

In this guideline, the World Health Organization (WHO) provides the most current and
relevant evidence-based global public health guidance on the initiation of treatment with …

Background In a previously reported randomized trial of standard and intensive systolic
blood-pressure control, data on some outcome events had yet to be adjudicated and post …

Hypertension remains an important public health challenge in the United States because it
increases the risk for cardiovascular disease. Effective blood pressure management has …

Background The most appropriate targets for systolic blood pressure to reduce
cardiovascular morbidity and mortality among persons without diabetes remain uncertain …

Importance The appropriate treatment target for systolic blood pressure (SBP) in older
patients with hypertension remains uncertain. Objective To evaluate the effects of intensive …

The appropriate target for BP in patients with CKD and hypertension remains uncertain. We
report prespecified subgroup analyses of outcomes in participants with baseline CKD in the …

Hypertension is a highly prevalent condition which has been established as a risk factor for
cardiovascular and cerebrovascular disease. Although the understanding of the relationship …