Toll‐like receptors (TLRs) are the important mediators of inflammatory pathways in the gut
which play a major role in mediating the immune responses towards a wide variety of …

Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …

m6A RNA modification is implicated in multiple cellular responses. However, its function in
the innate immune cells is poorly understood. Here, we identified major m6A “writers” as the …

Oxidative stress refers to elevated intracellular levels of reactive oxygen species (ROS) that
cause damage to lipids, proteins and DNA. Oxidative stress has been linked to a myriad of …

Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents
to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A …

Microglia are the most abundant immune cells in the central nervous system (CNS), where
they interact with neurons and exhibit a wide array of functions in physiological and …

LPS is a potent trigger of macrophage-mediated inflammation. However, prolonged
exposure to LPS induces a state of tolerance that reprograms the inflammatory response …

Reactive oxygen species (ROS) are essential components of the innate immune response
against intracellular bacteria and it is thought that professional phagocytes generate ROS …

The innate immune system has a key role in the mammalian immune response. Recent
research has demonstrated that mitochondria participate in a broad range of innate immune …

Toll-like receptors (TLRs) are recognition molecules for multiple pathogens, including
bacteria, viruses, fungi, and parasites. TLR2 forms heterodimers with TLR1 and TLR6, which …