Benzene, a common industrial chemical and a component of gasoline, is radiomimetic and
exposure may lead progressively to aplastic anaemia, leukaemia, and multiple myeloma …

The mechanisms underlying the toxicity of ethanol have been the subject of much study, but
are not well understood. Unlike many selective pharmacological agents, ethanol clearly has …

Benzene, an important industrial chemical, is myelotoxic and leukemogenic in humans. It is
metabolized by cytochrome P450 2E1 to various phenolic metabolites which accumulate in …

Benzene is a widely recognized human carcinogen. The mechanism of DNA damage
induced by major benzene metabolites 1, 4-benzoquinone (1, 4-BQ) and hydroquinone (1, 4 …

Antioxidant and pro-oxidant effects of 14 naturally occurring polyphenols (PP) on rat liver
microsomal lipid peroxidation (LP) and hydroxyl radical (OH) production were studied in …

Occupational exposure to benzene, a major industrial chemical, has been associated with
various blood dyscrasias and increased incidence of acute myelogenous leukemia in …

Cytochrome P450 (CYP) 2E1 was the most efficient CYP enzyme that oxidized benzene to
soluble and covalently bound metabolites in rat and human liver microsomes. The covalent …

Chronic exposure to high concentrations of benzene, primarily by inhalation, can affect the
function of the human immune system. Limited data are available on the immunotoxic effects …

Abstract CYP2B1 and 2E1 oxidized toluene, aniline and monochlorobenzene (MCB) to
water-soluble metabolites and to products covalently binding to microsomal proteins from …

The production of formaldehyde from tris (hydroxymethyl) aminomethane (Tris) by
interaction with hydroxyl radicals (. OH) was studied, since the reaction mixture from the …