Genome stability is a crucial feature of eukaryotic organisms because its alteration drastically affects the normal development and survival of cells and the organism as a …
Transcriptional heterogeneity due to plasticity of the epigenetic state of chromatin contributes to tumour evolution, metastasis and drug resistance,–. However, the …
F Marlétaz, N Timoshevskaya, VA Timoshevskiy… - Nature, 2024 - nature.com
As the only surviving lineages of jawless fishes, hagfishes and lampreys provide a crucial window into early vertebrate evolution,–. Here we investigate the complex history, timing …
N Timoshevskaya, Kİ Eşkut, VA Timoshevskiy… - Cell reports, 2023 - cell.com
Programmed DNA loss is a gene silencing mechanism that is employed by several vertebrate and nonvertebrate lineages, including all living jawless vertebrates and …
N Vontzou, Y Pei, JC Mueller, R Reifová… - Current Opinion in …, 2023 - Elsevier
Highlights•The GRC's absence from the soma might mitigate germline-soma conflict.•Sex- specific copy number differences highlight the GRC's distorted transmission.•A …
JC Mueller, SA Schlebusch, Y Pei… - Molecular biology …, 2023 - academic.oup.com
The germline-restricted chromosome (GRC) is likely present in all songbird species but differs widely in size and gene content. This extra chromosome has been described as …
TC Dockendorff, B Estrem, J Reed, JR Simmons… - Current Biology, 2022 - cell.com
Programmed DNA elimination (PDE) is a notable exception to the paradigm of genome integrity. In metazoa, PDE often occurs coincident with germline to somatic cell …
Programmed elimination of DNA during development yields somatic cell nuclei with dramatically different DNA sequence and content relative to germline nuclei, profoundly …
Simple Summary The present MS proposes a new hypothesis that motivates why only some animals can regenerate their organs. This derives from their simple body constitution …