Triggers and biological processes controlling male or female gonadal differentiation vary in
vertebrates, with sex determination (SD) governed by environmental factors or simple to …

Genome stability is a crucial feature of eukaryotic organisms because its alteration
drastically affects the normal development and survival of cells and the organism as a …

Transcriptional heterogeneity due to plasticity of the epigenetic state of chromatin
contributes to tumour evolution, metastasis and drug resistance,–. However, the …

As the only surviving lineages of jawless fishes, hagfishes and lampreys provide a crucial
window into early vertebrate evolution,–. Here we investigate the complex history, timing …

Programmed DNA loss is a gene silencing mechanism that is employed by several
vertebrate and nonvertebrate lineages, including all living jawless vertebrates and …

Highlights•The GRC's absence from the soma might mitigate germline-soma conflict.•Sex-
specific copy number differences highlight the GRC's distorted transmission.•A …

The germline-restricted chromosome (GRC) is likely present in all songbird species but
differs widely in size and gene content. This extra chromosome has been described as …

Programmed DNA elimination (PDE) is a notable exception to the paradigm of genome
integrity. In metazoa, PDE often occurs coincident with germline to somatic cell …

Programmed elimination of DNA during development yields somatic cell nuclei with
dramatically different DNA sequence and content relative to germline nuclei, profoundly …

Simple Summary The present MS proposes a new hypothesis that motivates why only some
animals can regenerate their organs. This derives from their simple body constitution …