Therapeutic potential of phenolic compounds in medicinal plants—Natural health products for human health

W Sun, MH Shahrajabian - Molecules, 2023 - mdpi.com
Phenolic compounds and flavonoids are potential substitutes for bioactive agents in
pharmaceutical and medicinal sections to promote human health and prevent and cure …

The role of natural anti-parasitic guided development of synthetic drugs for leishmaniasis

R Pal, G Teli, MJ Akhtar, GSP Matada - European Journal of Medicinal …, 2023 - Elsevier
Leishmaniasis is a parasitic disease and categorised as a neglected tropical disease (NTD).
Each year, between 70, 0000 and 1 million new cases are believed to occur. There are …

Coumarins from Rutaceae: Chemical diversity and biological activities

CMS Junior, SMC Silva, EM Sales, E da Silva Velozo… - Fitoterapia, 2023 - Elsevier
Rutaceae is a family expressed by approximately 2100 species distributed in 154 genera
widespread in tropical and temperate regions of Australasia, America, and South Africa …

Exploring biogenic chalcones as DprE1 inhibitors for antitubercular activity via in silico approach

S Rathod, P Chavan, D Mahuli, S Rochlani… - Journal of Molecular …, 2023 - Springer
Cases of drug-resistant tuberculosis (TB) have increased worldwide in the last few years,
and it is a major threat to global TB control strategies and the human population …

[HTML][HTML] Antidepressant effects of coumarins and their derivatives: A critical analysis of research advances

NA Akwu, M Lekhooa, D Deqiang, AO Aremu - European Journal of …, 2023 - Elsevier
Coumarins and their derivatives are non-flavonoids polyphenols with diverse
pharmacological activities including anti-depressant effects. This study systematically …

Novel 3-substituted coumarins inspire a custom pharmacology prediction pipeline: an anticancer discovery adventure

IK Matar, ZA Muhammad, SM Gomha… - Future Medicinal …, 2024 - Taylor & Francis
Aim: This research aims to expand the established pharmacological space of tumor-
associated carbonic anhydrases (TACAs) by exploring the synthetically accessible chemical …

13C NMR-based dereplication using MixONat software to decipher potent anti-cholinesterase compounds in Mesua lepidota bark

ST Leong, SY Liew, KY Khaw, HA Hassali… - Bioorganic …, 2023 - Elsevier
A bio-assay guided fractionation strategy based on cholinesterase assay combined with 13
C NMR-based dereplication was used to identify active metabolites from the bark of Mesua …

Structural and spectroscopic study of new copper (II) and zinc (II) complexes of coumarin oxyacetate ligands and determination of their antimicrobial activity

M Mujahid, N Trendafilova, G Rosair, K Kavanagh… - Molecules, 2023 - mdpi.com
Tackling antimicrobial resistance is of increasing concern in a post-pandemic world where
overuse of antibiotics has increased the threat of another pandemic caused by antimicrobial …

Synthesis, Antioxidant and Antiproliferative Evaluation, Molecular Docking and DFT Studies of Some Novel Coumarin and Fused Coumarin Derivatives

MAS Gouda, MAI Salem, MI Marzouk… - Chemistry & …, 2023 - Wiley Online Library
Abstract N′‐[(4‐Chloro‐2‐oxo‐2H‐chromen‐3‐yl) methylene]‐2‐cyanoacetohydrazide (3)
was synthesized in excellent yield from the condensation of 4‐Chloro‐2‐oxo‐2H‐chromene …

Evaluation of anti-inflammatory and anti-tubercular activity of 4-methyl-7-substituted coumarin hybrids and their structure activity relationships

M Nibin Joy, MR Guda, GV Zyryanov - Pharmaceuticals, 2023 - mdpi.com
Four sets of previously synthesized 4-methyl-7-substituted coumarin derivatives were
screened for their in vitro anti-inflammatory and anti-tubercular activities. The anti …