Klebsiella pneumoniae: adaptive immune landscapes and vaccine horizons

PL Wantuch, DA Rosen - Trends in Immunology, 2023 - cell.com
Klebsiella pneumoniae is among the most common antibiotic-resistant pathogens causing
nosocomial infections. Additionally, it is a leading cause of neonatal sepsis and childhood …

Vaccine development for bacterial pathogens: Advances, challenges and prospects

IE Mba, HC Sharndama… - Tropical Medicine & …, 2023 - Wiley Online Library
The advent and use of antimicrobials have played a key role in treating potentially life‐
threatening infectious diseases, improving health, and saving the lives of millions of people …

Design and fabrication of a vaccine candidate based on rOmpA from Klebsiella pneumoniae encapsulated in silk fibroin-sodium alginate nanoparticles against …

S Shahbazi, M Habibi, F Badmasti, S Sabzi… - International …, 2023 - Elsevier
The present study describes the design and fabrication of a novel vaccine candidate based
on the outer membrane protein A (rOmpA) from Klebsiella pneumoniae (K. pneumoniae) …

The Outer Membrane Proteins and Their Synergy Triggered the Protective Effects against Pathogenic Escherichia coli

G Pen, N Yang, D Teng, Y Hao, R Mao, J Wang - Microorganisms, 2022 - mdpi.com
Colibacillosis caused by pathogenic Escherichia coli (E. coli) is one of the most serious
infectious diseases, causing an extensive burden on animal husbandry and the human …

Animal models of Klebsiella pneumoniae mucosal infections

L Assoni, AJM Couto, B Vieira, B Milani… - Frontiers in …, 2024 - frontiersin.org
Klebsiella pneumoniae is among the most relevant pathogens worldwide, causing high
morbidity and mortality, which is worsened by the increasing rates of antibiotic resistance. It …

Characterization of Three New Outer Membrane Adhesion Proteins in Fusobacterium necrophorum

PK Bista, D Pillai, SK Narayanan - Microorganisms, 2023 - mdpi.com
Fusobacterium necrophorum, an anaerobic Gram-negative pathogen, causes necrotic cattle
infections, impacting livestock health and the US feedlot industry. Antibiotic administration is …

A New Live Auxotrophic Vaccine Induces Cross-Protection against Klebsiella pneumoniae Infections in Mice

M Moscoso, JA Vallejo, MP Cabral, P García… - Vaccines, 2022 - mdpi.com
The development of a whole-cell vaccine from bacteria auxotrophic for D-amino acids
present in the bacterial cell wall is considered a promising strategy for providing protection …

Single-dose of hybrid eukaryotic-prokaryotic nanovesicles to drive a rapid and controllable immune response against Klebsiella pneumoniae induced nosocomial …

L Jiang, L Ding, Q Long, X Liu, J Li, J Ma, Y Zheng… - Nano Today, 2024 - Elsevier
Klebsiella pneumoniae is the main pathogen of hospital-acquired infections causing acute
pneumonia, which is characterized by drug resistance, virulence and mortality, and for which …

[HTML][HTML] A rational designed multi-epitope vaccine elicited robust protective efficacy against Klebsiella pneumoniae lung infection

J Liao, X Zhang, X Zeng, Z Zhao, T Sun, Z Xia… - Biomedicine & …, 2024 - Elsevier
Background The emergence of drug-resistant strains of Klebsiella pneumoniae (K.
pneumoniae) has become a significant challenge in the field of infectious diseases, posing …

Vaccination with a trivalent Klebsiella pneumoniae vaccine confers protection in a murine model of pneumonia

Z Chen, Q Gou, Y Yuan, X Zhang, Z Zhao, J Liao… - Vaccine, 2024 - Elsevier
Klebsiella pneumoniae (K. pneumoniae) is an opportunistic pathogen and the major cause
of healthcare-associated infections, which are increasingly complicated by the prevalence of …