Many human tumor-associated antigens (TAAs) have recently been identified and
molecularly characterized. When bound to major histocompatibility complex molecules, TAA …

Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell
cycle and are required for the initiation and progression of various malignancies …

Metabolic activity is intimately linked to T cell fate and function. Using high-resolution mass
spectrometry, we generated dynamic metabolome and proteome profiles of human primary …

Tumour neoantigens arising from cancer-specific mutations generate a molecular fingerprint
that has a definite specificity for cancer. Although this fingerprint perfectly discriminates …

Stimulating the effector functions of tumor-infiltrating T lymphocytes (TIL) in primary and
metastatic tumors could improve active and adoptive T-cell therapies for cancer. Abnormal …

PURPOSE: Technologic advances have led to increased clinical use of higher-sized
fractions of radiation dose and higher total doses. How these modify the pathways involved …

Growing evidence supports the importance of gut microbiota in the control of tumor growth
and response to therapy. Here, we select prebiotics that can enrich bacterial taxa that …

Recent clinical trials showed that targeting of inhibitory receptors on T cells induces durable
responses in a subset of cancer patients, despite advanced disease. However, the …

Cytotoxic T lymphocytes (CTLs) play a major role in cancer immunotherapy because of their
ability to directly kill tumor cells and secrete tumor suppressive cytokines. Anticancer …

Adaptive immune responses to Ags released by dying cells play a critical role in the
development of autoimmunity, allograft rejection, and spontaneous as well as therapy …