Bifunctional degrader molecules, also called proteolysis-targeting chimeras (PROTACs), are
a new modality of chemical tools and potential therapeutics to understand and treat human …

The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …

DNA-encoded chemical library technologies are increasingly being adopted in drug
discovery for hit and lead generation. DNA-encoded chemistry enables the exploration of …

Carbohydrates are the most abundant class of energy yielding nutrients which is
economically indispensable in commercial fish feed formulations. But, the ability of farmed …

Our ever‐increasing understanding of biological systems is providing a range of exciting
novel biological targets, whose modulation may enable novel therapeutic options for many …

Zinc deficiency is a risk factor for obesity and diabetes. However, until recently, the
underlying molecular mechanisms remained unclear. The breakthrough discovery that the …

Upon its secretion from pancreatic β-cells, insulin reaches the liver through the portal
circulation to exert its action and eventually undergo clearance in the hepatocytes. In …

The past two decades have witnessed the emergence of macrocycles, including macrocyclic
peptides, as a promising yet underexploited class of de novo drug candidates. Both …

Type 2 diabetes (T2D) is a highly prevalent and chronic metabolic disorder. Recent
evidence suggests that formation of toxic aggregates of the islet amyloid polypeptide (IAPP) …

In recent years, DNA-encoded chemical libraries (DECLs) have attracted considerable
attention as a potential discovery tool in drug development. Screening encoded libraries …