The clinical implications of mouse models of enhanced anxiety

SB Sartori, R Landgraf, N Singewald - Future neurology, 2011 - Taylor & Francis
Mice are increasingly overtaking the rat model organism in important aspects of anxiety
research, including drug development. However, translating the results obtained in mouse …

Personality driven alcohol and drug abuse: New mechanisms revealed

MN Skóra, T Pattij, A Beroun, G Kogias… - Neuroscience & …, 2020 - Elsevier
While the majority of the regular consumers of alcohol controls their consumption well over
life span and even takes instrumentalization benefits from it, a minority, but yet high total …

High-anxious individuals show increased chronic stress burden, decreased protective immunity, and increased cancer progression in a mouse model of squamous …

FS Dhabhar, AN Saul, TH Holmes, C Daugherty… - PLoS …, 2012 - journals.plos.org
In spite of widespread anecdotal and scientific evidence much remains to be understood
about the long-suspected connection between psychological factors and susceptibility to …

Neurochemical mechanisms of alcohol withdrawal

HC Becker, PJ Mulholland - Handbook of clinical neurology, 2014 - Elsevier
Alcohol dependence encompasses a serious medical and societal problem that constitutes
a major public health concern. A serious consequence of dependence is the emergence of …

Characterization of an alcohol addiction‐prone phenotype in mice

K Radwanska, L Kaczmarek - Addiction biology, 2012 - Wiley Online Library
Human studies indicate that high impulsivity, novelty seeking and anxiety predispose
individuals to alcohol abuse. Unclear, however, is whether the same phenotypes can be …

Interaction between stress and addiction: Contributions from Latin-American neuroscience

A Torres-Berrio, S Cuesta, S Lopez-Guzman… - Frontiers in …, 2018 - frontiersin.org
Drug addiction is a chronic neuropsychiatric disorder that escalates from an initial exposure
to drugs of abuse, such as cocaine, cannabis, or heroin, to compulsive drug-seeking and …

Individual differences in elevated plus-maze exploration predicted higher ethanol consumption and preference in outbred mice

A Bahi - Pharmacology Biochemistry and Behavior, 2013 - Elsevier
Psychiatric illnesses, such as anxiety, are highly comorbid with drug use disorders in
general and alcohol abuse in particular. Unfortunately, the causal role of anxiety in ethanol …

Relaxin-3 receptor (RXFP3) signalling mediates stress-related alcohol preference in mice

AW Walker, CM Smith, BE Chua, EV Krstew, C Zhang… - PLoS …, 2015 - journals.plos.org
Stressful life events are causally linked with alcohol use disorders (AUDs), providing support
for a hypothesis that alcohol consumption is aimed at stress reduction. We have previously …

Categories of wistar rats based on anxiety traits: a study using factor and cluster method

A Radhakrishnan, KK Gulia - Annals of Neurosciences, 2019 - karger.com
Background: Outcomes of neurobehavioral studies are invariably affected by the variations
in the anxiety traits of animals in the same species. Identifying those traits and categorizing …

Ethanol pre‐exposure during adolescence or adulthood increases ethanol intake but ethanol‐induced conditioned place preference is enhanced only when pre …

PF Carrara‐Nascimento, MF Olive… - Developmental …, 2014 - Wiley Online Library
Behavioral sensitization has been suggested to contribute to uncontrolled alcohol
consumption. The aim of this study was to investigate the effects of repeated ethanol …