Identification and quantification of proteoforms by mass spectrometry
A proteoform is a defined form of a protein derived from a given gene with a specific amino
acid sequence and localized post‐translational modifications. In top‐down proteomic …
acid sequence and localized post‐translational modifications. In top‐down proteomic …
Top-down proteomics
Proteoforms, which arise from post-translational modifications, genetic polymorphisms and
RNA splice variants, play a pivotal role as drivers in biology. Understanding proteoforms is …
RNA splice variants, play a pivotal role as drivers in biology. Understanding proteoforms is …
Proteoform characterization based on top-down mass spectrometry
Proteins are dominant executors of living processes. Compared to genetic variations,
changes in the molecular structure and state of a protein (ie proteoforms) are more directly …
changes in the molecular structure and state of a protein (ie proteoforms) are more directly …
Development of analytical and bioinformatics strategies in mass spectrometry for the characterization of therapeutic proteins and their impurities
C Beaumal - 2023 - theses.hal.science
Mass spectrometry has been a technique of choice for the characterization of proteins. This
Ph. D. work aims to develop analytical and bioinformatics strategies in mass spectrometry to …
Ph. D. work aims to develop analytical and bioinformatics strategies in mass spectrometry to …
TopPIC Gateway: A web gateway for top-down mass spectrometry data interpretation
Top-down mass spectrometry-based proteomics has become the method of choice for
identifying and quantifying intact proteoforms in biological samples. We present a web …
identifying and quantifying intact proteoforms in biological samples. We present a web …