Articular cartilage is commonly described as a tissue that is made of up to 80% water, is
devoid of blood vessels, nerves, and lymphatics, and is populated by only one cell type, the …

Osteoarthritis is a common joint disease for which there are currently no disease-modifying
drugs available. Degradation of the cartilage extracellular matrix is a central feature of the …

Temporomandibular joint (TMJ) disorders have complex and sometimes controversial
etiologies. Also, under similar circumstances, one person's TMJ may appear to deteriorate …

End plates serve as the interface between rigid vertebral bodies and pliant intervertebral
disks. Because the lumbar spine carries significant forces and disks don't have a dedicated …

The composition and organisation of the extracellular matrix (ECM), particularly the
pericellular matrix (PCM), in articular cartilage is critical to its biomechanical functionality; the …

Primary cilia are sensory organelles that translate extracellular chemical and mechanical
cues into cellular responses. Bone is an exquisitely mechanosensitive organ, and its …

Bone tissue has the capacity to adapt to its functional environment such that its morphology
is “optimized” for the mechanical demand. The adaptive nature of the skeleton poses an …

The development, maintenance, and destruction of cartilage are regulated by mechanical
factors throughout life. Mechanical cues in the cartilage fetal endoskeleton influence the …

Cartilage has a poor intrinsic healing response, and neither the innate healing response nor
current clinical treatments can restore its function. Therefore, articular cartilage tissue …

Objective By producing instability in mouse knee joints, we attempted to determine the
involvement of runt‐related transcription factor 2 (RUNX‐2), which is required for …