Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Mitochondrial function is key to support metabolism and homeostasis in the retina, an organ
that has one of the highest metabolic rates body-wide and is constantly exposed to …

Retinitis pigmentosa (RP) is an important cause of irreversible blindness worldwide and
lacks effective treatment strategies. Although mutations are the primary cause of RP …

Autophagy is a fundamental homeostatic pathway that mediates the degradation and
recycling of intracellular components. It serves as a key quality control mechanism …

Programmed cell death (PCD) is a highly regulated process that results in the orderly
destruction of a cell. Many different forms of PCD may be distinguished, including apoptosis …

Elucidation of the cellular changes that occur in degenerating photoreceptors of people with
inherited retinal diseases (IRDs) has been a focus for many research teams, leading to …

The critical role of epigenetic modification of histones in maintaining the normal function of
the nervous system has attracted increasing attention. Among these modifications, the level …

Inherited retinal diseases (IRDs) are a leading cause of blindness. To date, 260 disease-
causing genes have been identified, but there is currently a lack of available and effective …

Inherited retinal diseases, which include retinitis pigmentosa, are a family of genetic
disorders characterized by gradual rod-cone degeneration and vision loss, without effective …

Glaucoma is considered a neurodegenerative disease characterized by progressive visual
field defects that may lead to blindness. Although controlling intraocular pressure (IOP) is the …