[HTML][HTML] Advances and challenges in stem cell culture

C McKee, GR Chaudhry - Colloids and surfaces B: Biointerfaces, 2017 - Elsevier
Stem cells (SCs) hold great promise for cell therapy, tissue engineering, and regenerative
medicine as well as pharmaceutical and biotechnological applications. They have the …

[HTML][HTML] Application of human mesenchymal and pluripotent stem cell microcarrier cultures in cellular therapy: achievements and future direction

AKL Chen, S Reuveny, SKW Oh - Biotechnology advances, 2013 - Elsevier
Mesenchymal stem cells (MSCs) have recently made significant progress with multiple
clinical trials targeting modulation of immune responses, regeneration of bone, cartilage …

Advances in cell culture: anchorage dependence

OW Merten - … Transactions of the Royal Society B …, 2015 - royalsocietypublishing.org
Anchorage-dependent cells are of great interest for various biotechnological applications.(i)
They represent a formidable production means of viruses for vaccination purposes at very …

Allogeneic cell therapy bioprocess economics and optimization: Single‐use cell expansion technologies

AS Simaria, S Hassan, H Varadaraju… - Biotechnology and …, 2014 - Wiley Online Library
For allogeneic cell therapies to reach their therapeutic potential, challenges related to
achieving scalable and robust manufacturing processes will need to be addressed. A …

Bioprocessing strategies for the large-scale production of human mesenchymal stem cells: a review

KM Panchalingam, S Jung, L Rosenberg… - Stem cell research & …, 2015 - Springer
Human mesenchymal stem cells (hMSCs), also called mesenchymal stromal cells, have
been of great interest in regenerative medicine applications because of not only their …

Microcarrier culture for efficient expansion and osteogenic differentiation of human fetal mesenchymal stem cells

TKP Goh, ZY Zhang, AKL Chen, S Reuveny… - BioResearch open …, 2013 - liebertpub.com
Stirred microcarrier (MC) culture has been suggested as the method of choice for supplying
large volumes of mesenchymal stem cells (MSCs) for bone tissue engineering. In this study …

Clinical applications for exosomes: Are we there yet?

D Perocheau, L Touramanidou… - British journal of …, 2021 - Wiley Online Library
Exosomes are a subset of extracellular vesicles essential for cell–cell communication in
health and disease with the ability to transport nucleic acids, functional proteins and other …

Large‐scale production of human mesenchymal stem cells for clinical applications

S Jung, KM Panchalingam, RD Wuerth… - Biotechnology and …, 2012 - Wiley Online Library
Human mesenchymal stem cells (hMSCs) have many potential applications in tissue
engineering and regenerative medicine. Currently, hMSCs are generated through …

[HTML][HTML] Impact of allogeneic stem cell manufacturing decisions on cost of goods, process robustness and reimbursement

TDP Chilima, F Moncaubeig, SS Farid - Biochemical Engineering Journal, 2018 - Elsevier
This article presents a framework to evaluate holistically the operational and economic
performance of different manufacturing platforms for the expansion of allogeneic …

Engineering stem cell fate with biochemical and biomechanical properties of microcarriers

S Sart, SN Agathos, Y Li - Biotechnology progress, 2013 - Wiley Online Library
Microcarriers have been widely used for various biotechnology applications because of their
high scale‐up potential, high reproducibility in regulating cellular behavior, and well …