Network regulation of microRNA biogenesis and target interaction
S Komatsu, H Kitai, HI Suzuki - Cells, 2023 - mdpi.com
MicroRNAs (miRNAs) are versatile, post-transcriptional regulators of gene expression.
Canonical miRNAs are generated through the two-step DROSHA-and DICER-mediated …
Canonical miRNAs are generated through the two-step DROSHA-and DICER-mediated …
The miRNA–target interactions: An underestimated intricacy
MicroRNAs (miRNAs) play indispensable roles in posttranscriptional gene regulation. Their
cellular regulatory impact is determined not solely by their sheer number, which likely …
cellular regulatory impact is determined not solely by their sheer number, which likely …
Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo
Summary Polycomb repressive complex 2 (PRC2) is reported to bind to many RNAs and
has become a central player in reports of how long non-coding RNAs (lncRNAs) regulate …
has become a central player in reports of how long non-coding RNAs (lncRNAs) regulate …
ZSWIM8 destabilizes many murine microRNAs and is required for proper embryonic growth and development
MicroRNAs (miRNAs) pair to sites in mRNAs to direct the degradation of these RNA
transcripts. Conversely, certain RNA transcripts can direct the degradation of particular …
transcripts. Conversely, certain RNA transcripts can direct the degradation of particular …
Multiscale profiling of protease activity in cancer
Diverse processes in cancer are mediated by enzymes, which most proximally exert their
function through their activity. High-fidelity methods to profile enzyme activity are therefore …
function through their activity. High-fidelity methods to profile enzyme activity are therefore …
HaloTag‐Based Reporters for Fluorescence Imaging and Biosensing
A Cook, F Walterspiel, C Deo - ChemBioChem, 2023 - Wiley Online Library
Visualizing the structure and dynamics of biomolecules is critical to understand biological
function, and requires methods to fluorescently label targets of interest in their cellular …
function, and requires methods to fluorescently label targets of interest in their cellular …
TRERNA1 upregulation mediated by HBx promotes sorafenib resistance and cell proliferation in HCC via targeting NRAS by sponging miR-22-3p
W Song, C Zheng, M Liu, Y Xu, Y Qian, Z Zhang, H Su… - Molecular Therapy, 2021 - cell.com
Hepatocellular carcinoma (HCC) is among the most common malignancies and has an
unfavorable prognosis. The hepatitis B virus-encoded X (HBx) protein is closely associated …
unfavorable prognosis. The hepatitis B virus-encoded X (HBx) protein is closely associated …
Convergence of multiple RNA-silencing pathways on GW182/TNRC6
The RNA-binding protein TRIM71/LIN-41 is a phylogenetically conserved developmental
regulator that functions in mammalian stem cell reprogramming, brain development, and …
regulator that functions in mammalian stem cell reprogramming, brain development, and …
Oncogenic K-Ras suppresses global miRNA function
K-Ras frequently acquires gain-of-function mutations (K-Ras G12D being the most common)
that trigger significant transcriptomic and proteomic changes to drive tumorigenesis …
that trigger significant transcriptomic and proteomic changes to drive tumorigenesis …
MicroRNA regulation of critical retinal pigment epithelial functions
SW Du, K Palczewski - Trends in neurosciences, 2022 - cell.com
MicroRNAs are short, evolutionarily conserved noncoding RNAs that are critical for the
control of normal cellular physiology. In the retina, photoreceptors are highly specialized …
control of normal cellular physiology. In the retina, photoreceptors are highly specialized …