The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

Although the classic activities of p53 including induction of cell-cycle arrest, senescence,
and apoptosis are well accepted as critical barriers to cancer development, accumulating …

Nitric oxide (NO) is a pleiotropic molecule critical to a number of physiological and
pathological processes. The last decade has witnessed major advances in dissecting NO …

Utilizing targeted therapies capable of reducing cancer metastasis, targeting chemoresistant
and self-renewing cancer stem cells, and augmenting the efficacy of systemic …

To date, the most immunotherapy drugs act upon T cell surface proteins to promote
tumoricidal T cell activity. However, this approach has to date been unsuccessful in certain …

Nitric oxide (NO), a short-lived, endogenously produced gas, plays key role in various
physiological as well as pathological processes. NO-inducing cell signaling events within …

Abstract Cyclooxygenase 2 (COX-2), also called prostaglandin endoperoxide synthase 2, is
involved in colorectal tumor development. This review deals with particular questions raised …

Lung cancer is the leading cause of cancer-related deaths worldwide. Despite decades of
research, the treatment options for lung cancer patients remain inadequate, either to offer a …

UV-irradiated skin and UV-induced tumors overexpress the inducible isoform of
cyclooxygenase-2 (Cox-2), and Cox-2 inhibition reduces photocarcinogenesis. To evaluate …

It is known that the relationship between pro-angiogenic and anti-angiogenic factors is
responsible for the presence and intensity of neoangiogenesis. The angiogenic factors are …