Inflammatory cytokines in acute ischemic stroke
A Tuttolomondo, D Di Raimondo… - Current …, 2008 - ingentaconnect.com
Three major cytokines, namely, tumor necrosis factor (TNF-α), interleukin (IL)-1, and IL-6 are
produced by cultured brain cells after various stimuli such as ischemia. Neurones …
produced by cultured brain cells after various stimuli such as ischemia. Neurones …
Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation
Inflammation is a classical host defence response to infection and injury that has many
beneficial effects. However, inappropriate (in time, place and magnitude) inflammation is …
beneficial effects. However, inappropriate (in time, place and magnitude) inflammation is …
A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients
Objectives: The cytokine interleukin (IL)-1 mediates ischaemic brain damage in rodents. The
endogenous, highly selective, IL-1 receptor antagonist (IL-1ra) protects against ischaemic …
endogenous, highly selective, IL-1 receptor antagonist (IL-1ra) protects against ischaemic …
Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke.
ES Connolly, CJ Winfree, TA Springer… - The Journal of …, 1996 - Am Soc Clin Investig
Acute neutrophil (PMN) recruitment to postischemic cardiac or pulmonary tissue has
deleterious effects in the early reperfusion period, but the mechanisms and effects of …
deleterious effects in the early reperfusion period, but the mechanisms and effects of …
Early neutrophilia is associated with volume of ischemic tissue in acute stroke
Background and Purpose—Few data exist on the relationship between differential
subpopulations of peripheral leukocytes and early cerebral infarct size in ischemic stroke …
subpopulations of peripheral leukocytes and early cerebral infarct size in ischemic stroke …
Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke.
PM Kochanek, JM Hallenbeck - Stroke, 1992 - Am Heart Assoc
The extent to which polymorphonuclear leukocytes and monocytes/macrophages contribute
to the pathobiology of cerebral ischemia and stroke is an issue of long-standing …
to the pathobiology of cerebral ischemia and stroke is an issue of long-standing …
An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis
HCA Emsley, CJ Smith, CM Gavin, RF Georgiou… - Journal of …, 2003 - Elsevier
Central nervous system and peripheral inflammation is important in the responses to
ischaemic stroke, and may also predispose to its development. We aimed to identify (1) the …
ischaemic stroke, and may also predispose to its development. We aimed to identify (1) the …
Reperfusion injury after focal cerebral ischemia: the role of inflammation and the therapeutic horizon
Abstract RECENT EVIDENCE INDICATES that thrombolysis may be an effective therapy for
the treatment of acute ischemic stroke. However, the reperfusion of ischemic brain comes …
the treatment of acute ischemic stroke. However, the reperfusion of ischemic brain comes …
Inflammation and infection in clinical stroke
HCA Emsley, PJ Tyrrell - Journal of Cerebral Blood Flow & …, 2002 - journals.sagepub.com
Stroke has enormous clinical, social, and economic implications, and demands a significant
effort from both basic and clinical science in the search for successful therapies …
effort from both basic and clinical science in the search for successful therapies …
Serial measurement of interleukin-6, transforming growth factor-β, and S-100 protein in patients with acute stroke
JS Kim, SS Yoon, YH Kim, JS Ryu - Stroke, 1996 - Am Heart Assoc
Background and Purpose Cytokine changes in patients with acute stroke have been
insufficiently studied. The purpose of this study was to delineate the characteristics of serial …
insufficiently studied. The purpose of this study was to delineate the characteristics of serial …