Acetylcholinesterase inhibitors in the treatment of neurodegenerative diseases and the role of acetylcholinesterase in their pathogenesis

ŁJ Walczak-Nowicka, M Herbet - International journal of molecular …, 2021 - mdpi.com
Acetylcholinesterase (AChE) plays an important role in the pathogenesis of
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …

Neuroprotective effects of cholinesterase inhibitors: current scenario in therapies for Alzheimer's disease and future perspectives

NCS Moreira, JEBF Lima, MF Marchiori… - Journal of …, 2022 - content.iospress.com
Alzheimer's disease (AD) is a slowly progressive neurodegenerative disease
conceptualized as a continuous process, ranging from mild cognitive impairment (MCI), to …

[HTML][HTML] X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women

Y Yan, X Wang, D Chaput, MK Shin, Y Koh, L Gan… - Cell, 2022 - cell.com
Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

Exploring the inhibition of quercetin on acetylcholinesterase by multispectroscopic and in silico approaches and evaluation of its neuroprotective effects on PC12 cells

Y Liao, X Mai, X Wu, X Hu, X Luo, G Zhang - Molecules, 2022 - mdpi.com
This study investigated the inhibitory mechanism of quercetin in acetylcholinesterase
(AChE) and its neuroprotective effects on β-amyloid25–35-induced oxidative stress injury in …

Unveiling the multitarget anti-Alzheimer drug discovery landscape: A bibliometric analysis

A Sampietro, FJ Pérez-Areales, P Martínez, EM Arce… - Pharmaceuticals, 2022 - mdpi.com
Multitarget anti-Alzheimer agents are the focus of very intensive research. Through a
comprehensive bibliometric analysis of the publications in the period 1990–2020, we have …

Recent Development in the Understanding of Molecular and Cellular Mechanisms Underlying the Etiopathogenesis of Alzheimer's Disease

A Afsar, MC Chacon Castro, AS Soladogun… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to
dementia and patient death. AD is characterized by intracellular neurofibrillary tangles …

Effects of linkers and substitutions on multitarget directed ligands for Alzheimer's diseases: Emerging paradigms and strategies

N Pravin, K Jozwiak - International journal of molecular sciences, 2022 - mdpi.com
Alzheimer's disease (AD) is multifactorial, progressive and the most predominant cause of
cognitive impairment and dementia worldwide. The current “one-drug, one-target” approach …

Tacrine-based hybrids: past, present, and future

A Bubley, A Erofeev, P Gorelkin… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder which is characterized by β-
amyloid (Aβ) aggregation, τ-hyperphosphorylation, and loss of cholinergic neurons. The …

A review on α-mangostin as a potential multi-target-directed ligand for Alzheimer's disease

A Yang, C Liu, J Wu, X Kou, R Shen - European Journal of Pharmacology, 2021 - Elsevier
Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by
progressive memory loss, declining language skills and other cognitive disorders. AD has …

Ginkgo biloba: Antioxidant Activity and In Silico Central Nervous System Potential

E Suárez-González, J Sandoval-Ramírez… - Current Issues in …, 2023 - mdpi.com
Ginkgo biloba (GB) extracts have been used in clinical studies as an alternative therapy for
Alzheimer's disease (AD), but the exact bioaction mechanism has not yet been elucidated. In …