Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Since the identification of the causative gene in Huntington's disease (HD), a number of
animal models of this disorder have been developed. A frequently asked question is: which …

Huntington's disease is a neurodegenerative disorder caused by a polyglutamine repeat in
the Huntingtin gene (HTT). Although suppressing the expression of mutant HTT (mHTT) has …

Although it is well established that Huntington's disease (HD) is mainly caused by
polyglutamine-expanded mutant huntingtin (mHTT), the molecular mechanism of mHTT …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder
characterized by motor, cognitive and psychiatric manifestations. Since the mutation …

In many repeat diseases, such as Huntington's disease (HD), ongoing repeat expansions in
affected tissues contribute to disease onset, progression and severity. Inducing contractions …

Huntington's disease (HD) is an inherited neurodegenerative disease caused by a
glutamine repeat expansion in huntingtin protein. Transcriptional deregulation and altered …

An expanded CAG repeat is the underlying genetic defect in Huntington disease, a disorder
characterized by motor, psychiatric and cognitive deficits and striatal atrophy associated with …

To elucidate the pathogenic mechanisms in Huntington's disease (HD) elicited by
expression of full-length human mutant huntingtin (fl-mhtt), a bacterial artificial chromosome …

Lengthening a glutamine tract in huntingtin confers a dominant attribute that initiates
degeneration of striatal neurons in Huntington's disease (HD). To identify pathways that are …