The current toolbox for APOBEC drug discovery
MJ Grillo, KFM Jones, MA Carpenter, RS Harris… - Trends in …, 2022 - cell.com
Mutational processes driving genome evolution and heterogeneity contribute to immune
evasion and therapy resistance in viral infections and cancer. APOBEC3 (A3) enzymes …
evasion and therapy resistance in viral infections and cancer. APOBEC3 (A3) enzymes …
The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead
M Granadillo Rodriguez, B Flath… - Open Biology, 2020 - royalsocietypublishing.org
Cancer is considered a group of diseases characterized by uncontrolled growth and spread
of abnormal cells and is propelled by somatic mutations. Apolipoprotein B mRNA-editing …
of abnormal cells and is propelled by somatic mutations. Apolipoprotein B mRNA-editing …
Competition for DNA binding between the genome protector replication protein A and the genome modifying APOBEC3 single-stranded DNA deaminases
The human APOBEC family of eleven cytosine deaminases use RNA and single-stranded
DNA (ssDNA) as substrates to deaminate cytosine to uracil. This deamination event has …
DNA (ssDNA) as substrates to deaminate cytosine to uracil. This deamination event has …
Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure
YZ McDaniel, D Wang, RP Love… - Nucleic acids …, 2020 - academic.oup.com
The human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (APOBEC3,
A3) family member proteins can deaminate cytosines in single-strand (ss) DNA, which …
A3) family member proteins can deaminate cytosines in single-strand (ss) DNA, which …
Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B
The single-stranded DNA cytidine deaminases APOBEC3B, APOBEC3H haplotype I, and
APOBEC3A can contribute to cancer through deamination of cytosine to form promutagenic …
APOBEC3A can contribute to cancer through deamination of cytosine to form promutagenic …
A single nucleotide polymorphism in human APOBEC3C enhances restriction of lentiviruses
Humans express seven human APOBEC3 proteins, which can inhibit viruses and
endogenous retroelements through cytidine deaminase activity. The seven paralogs differ in …
endogenous retroelements through cytidine deaminase activity. The seven paralogs differ in …
Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer
A prominent source of mutation in cancer is single-stranded DNA cytosine deamination by
cellular APOBEC3 enzymes, which results in signature C-to-T and C-to-G mutations in TCA …
cellular APOBEC3 enzymes, which results in signature C-to-T and C-to-G mutations in TCA …
Nuclear magnetic resonance structure of the APOBEC3B catalytic domain: structural basis for substrate binding and DNA deaminase activity
Human APOBEC3B (A3B) is a member of the APOBEC3 (A3) family of cytidine deaminases,
which function as DNA mutators and restrict viral pathogens and endogenous …
which function as DNA mutators and restrict viral pathogens and endogenous …
APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA
The APOBEC3 family of cytidine deaminases cause lethal hypermutation of retroviruses via
deamination of newly reverse-transcribed viral DNA. Their ability to bind RNA is essential for …
deamination of newly reverse-transcribed viral DNA. Their ability to bind RNA is essential for …
Protein interaction map of APOBEC3 enzyme family reveals deamination-independent role in cellular function
GM Jang, AKA Sudarsan, A Shayeganmehr… - Molecular & Cellular …, 2024 - ASBMB
Human APOBEC3 enzymes are a family of single-stranded (ss) DNA and RNA cytidine
deaminases that act as part of the intrinsic immunity against viruses and retroelements …
deaminases that act as part of the intrinsic immunity against viruses and retroelements …