Roadmap for metal nanoparticles in radiation therapy: Current status, translational challenges, and future directions

J Schuemann, AF Bagley, R Berbeco… - Physics in Medicine …, 2020 - iopscience.iop.org
This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of
radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z= 22, to …

Mechanistic modelling of radiation responses

SJ McMahon, KM Prise - Cancers, 2019 - mdpi.com
Radiobiological modelling has been a key part of radiation biology and therapy for many
decades, and many aspects of clinical practice are guided by tools such as the linear …

TOPAS-nBio: an extension to the TOPAS simulation toolkit for cellular and sub-cellular radiobiology

J Schuemann, AL McNamara… - Radiation …, 2019 - meridian.allenpress.com
The TOPAS Monte Carlo (MC) system is used in radiation therapy and medical imaging
research, having played a significant role in making Monte Carlo simulations widely …

A new standard DNA damage (SDD) data format

J Schuemann, AL McNamara… - Radiation …, 2019 - meridian.allenpress.com
Our understanding of radiation-induced cellular damage has greatly improved over the past
few decades. Despite this progress, there are still many obstacles to fully understand how …

A mechanistic DNA repair and survival model (Medras): applications to intrinsic radiosensitivity, relative biological effectiveness and dose-rate

SJ McMahon, KM Prise - Frontiers in Oncology, 2021 - frontiersin.org
Variations in the intrinsic radiosensitivity of different cells to ionizing radiation is now widely
believed to be a significant driver in differences in response to radiotherapy. While the …

Modelling radiobiology

LL Gardner, SJ Thompson, JD O'Connor… - Physics in Medicine …, 2024 - iopscience.iop.org
Radiotherapy has played an essential role in cancer treatment for over a century, and
remains one of the best-studied methods of cancer treatment. Because of its close links with …

Cellular response to proton irradiation: a simulation study with TOPAS-nBio

H Zhu, AL McNamara, SJ McMahon… - Radiation …, 2020 - meridian.allenpress.com
The cellular response to ionizing radiation continues to be of significant research interest in
cancer radiotherapy, and DNA is recognized as the critical target for most of the biologic …

Models for translational proton radiobiology—from bench to bedside and back

T Suckert, S Nexhipi, A Dietrich, R Koch… - Cancers, 2021 - mdpi.com
Simple Summary An increasing number of cancer patients are treated with proton therapy.
Nevertheless, there are still open questions that require preclinical studies, for example …

A parameter sensitivity study for simulating DNA damage after proton irradiation using TOPAS-nBio

H Zhu, AL McNamara, J Ramos-Mendez… - Physics in Medicine …, 2020 - iopscience.iop.org
Monte Carlo (MC) track structure simulation tools are commonly used for predicting radiation
induced DNA damage by modeling the physical and chemical reactions at the nanometer …

Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit

AL McNamara, J Ramos-Méndez, J Perl… - Physics in Medicine …, 2018 - iopscience.iop.org
Computational simulations, such as Monte Carlo track structure simulations, offer a powerful
tool for quantitatively investigating radiation interactions within cells. The modelling of the …