Role of oxidative stress as key regulator of muscle wasting during cachexia

J Ábrigo, AA Elorza, CA Riedel, C Vilos… - Oxidative medicine …, 2018 - Wiley Online Library
Skeletal muscle atrophy is a pathological condition mainly characterized by a loss of
muscular mass and the contractile capacity of the skeletal muscle as a consequence of …

Regulation of metabolism and growth during immune challenge: an overview of cytokine function

ME Spurlock - Journal of animal science, 1997 - academic.oup.com
Commercially reared food animals encounter serial pathogenic and nonpathogenic immune
challenges throughout production. Because of the diversion of nutrients away from growth in …

The Regulation of Skeletal Muscle Protein Turnover during the Progression of Cancer Cachexia in the ApcMin/+ Mouse

JP White, JW Baynes, SL Welle, MC Kostek… - PloS one, 2011 - journals.plos.org
Muscle wasting that occurs with cancer cachexia is caused by an imbalance in the rates of
muscle protein synthesis and degradation. The ApcMin/+ mouse is a model of colorectal …

[图书][B] Seasonal patterns of stress, immune function, and disease

RJ Nelson, GE Demas, SL Klein, LJ Kriegsfeld - 2002 - books.google.com
This book presents evidence that infection is cyclical with the seasons, and that this
phenomenon is mirrored in cycles of immune function. The book identifies the mechanisms …

The relationships among IGF-1, DNA content, and protein accumulation during skeletal muscle hypertrophy

GR Adams, F Haddad - Journal of applied physiology, 1996 - journals.physiology.org
Adams, GR, and F. Haddad. The relationships among IGF-1, DNA content, and protein
accumulation during skeletal muscle hypertrophy. J. Appl. Physiol. 81 (6): 2509–2516, 1996 …

Differential transcriptomic profiles following stimulation with lipopolysaccharide in intestinal organoids from dogs with inflammatory bowel disease and intestinal mast …

DK Sahoo, DC Borcherding, L Chandra, AE Jergens… - Cancers, 2022 - mdpi.com
Simple Summary Lipopolysaccharide (LPS) derived from intestinal bacteria is linked to long-
lasting inflammation that contributes to the development of intestinal cancer. While much …

IGF-1 is downregulated in experimental cancer cachexia

P Costelli, M Muscaritoli, M Bossola… - American Journal …, 2006 - journals.physiology.org
Cancer cachexia is characterized by skeletal muscle wasting that is mainly supported by
hypercatabolism. Muscle atrophy has been suggested to depend on impaired IGF-1 signal …

Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) in immunity and inflammation

VH Heemskerk, MARC Daemen… - Cytokine & growth factor …, 1999 - Elsevier
In recent years many efforts have been undertaken to elucidate the complex interactions
between mediators of the endocrine system and the immune system. The main effector of …

Effect of chronic immune system activation on the rate, efficiency, and composition of growth and lysine needs of pigs fed from 6 to 27 kg

NH Williams, TS Stahly… - Journal of Animal …, 1997 - academic.oup.com
The influence of a low and a high level chronic immune system (IS) activation on growth and
dietary nutrient needs of pigs was evaluated. All pigs were of a single genetic strain and …

Protein kinase B/Akt: a nexus of growth factor and cytokine signaling in determining muscle mass

RA Frost, CH Lang - Journal of applied physiology, 2007 - journals.physiology.org
Although the boundaries of skeletal muscle size are fundamentally determined by genetics,
this dynamic tissue also demonstrates great plasticity in response to environmental and …