Abstract High hyperdiploidy (51–67 chromosomes) is the most common cytogenetic
abnormality pattern in childhood B‐cell precursor acute lymphoblastic leukemia (ALL) …

The regulator of G-protein signaling (RGS) family is a diverse group of multifunctional
proteins that regulate cellular signaling events downstream of G-protein coupled receptors …

Until recently, our understanding of the genetic factors contributing to the pathogenesis of
acute lymphoblastic leukemia (ALL) has relied on the detection of gross chromosomal …

An important feature of cancer development and progression is the change in DNA
methylation patterns, characterized by the hypermethylation of specific genes concurrently …

Acute lymphoblastic leukemia (ALL) is classified as B‐lineage ALL (B‐ALL) and T‐lineage
ALL (T‐ALL). The incidence of ALL is almost three times higher in white than black children …

Although it has been suggested that mutations of the FLT3, NRAS, KRAS, and PTPN11
genes are particularly frequent in high hyperdiploid (> 50 chromosomes) pediatric acute …

Circular RNAs (circRNAs) have recently been confirmed to participate in different
pathological processes, including cancer progression. However, the role and precise …

Mitochondria are prominently understood as power houses producing ATP the primary
energy currency of the cell. However, mitochondria are also known to play an important role …

The IKZF 1 gene at 7p12. 2 codes for IKAROS (also termed IKZF 1), an essential
transcription factor in haematopoiesis involved primarily in lymphoid differentiation. Its …

We present here a genome-wide map of abnormalities found in diagnostic samples from 45
adults and adolescents with acute lymphoblastic leukemia (ALL). A 500K SNP array …