Background The relationship between surgery and anesthetic-induced immunosuppression
and cancer recurrence remains unresolved. Surgery and anesthesia stimulate the …

IMMUNE PATHOGENESIS The principal line of defense against cancer cell invasion and
metastasis is established via the host's innate and adaptive immune response. The key …

The epidemic of opioid crisis started getting recognised as a public health emergency in
view of increasing opioid-related deaths occurring due to undetected respiratory depression …

It is well known that local anesthetics have a broad spectrum of pharmacological actions,
acting as nerve blocks, and treating pain and cardiac arrhythmias via blocking of the sodium …

Awake craniotomy (AC), defined as the performance of at least part of an open cranial
procedure with the patient awake, has been tied to beneficial outcomes compared with …

Neuroendocrine differentiation (NED) marks a structural and functional feature of certain
cancers, including prostate cancer (PCa), whereby the malignant tissue contains a …

Background Retrospective studies of patients undergoing cancer surgery suggest the use of
local anesthesia may decrease tumor recurrence and improve survival. The mechanisms on …

Background A retrospective analysis of patients undergoing cancer surgery suggested that
using local anesthetics could reduce cancer recurrence and improve survival rate. Previous …

The role opioids play in the development of cancer metastasis and recurrence is far from
clear and appears to differ depending on the cancer cell type in question. Prospective …

Awake craniotomy for brain tumor resection is becoming a standard of care for lesions
residing within or in close proximity to regions presumed to have language or sensorimotor …