Augmented renal clearance (ARC) is a manifestation of enhanced renal function seen in
critically ill patients. The use of regular unadjusted doses of renally eliminated drugs in …

Background Pharmacokinetics (PK) are severely altered in critically ill patients due to
changes in volume of distribution (Vd) and/or drug clearance (Cl). This affects the target …

The effect of renal functional status on drug metabolism is a crucial consideration for
clinicians when determining the appropriate dosage of medications to administer. In critically …

Many critically ill patients display a supraphysiological renal function with enhanced renal
perfusion and glomerular hyperfiltration. This phenomenon described as augmented renal …

Objectives: Augmented renal clearance (ARC) is a state of enhanced renal function
commonly observed in 30%–65% of critically ill patients despite normal serum creatinine …

Background Augmented renal clearance (ARC), an increase in kidney function with
enhanced elimination of circulating solute, has been increasingly recognized in critically ill …

Objectives: The objectives of this study were to: 1) evaluate the prevalence of augmented
renal clearance in critically ill pediatric patients using vancomycin clearance; 2) derive the …

Children show important developmental and maturational changes, which may contribute
greatly to pharmacokinetic (PK) variability observed in pediatric patients. These PK …

OBJECTIVE This study aims to describe the population pharmacokinetics and
pharmacodynamic target attainment of meropenem in critically ill children. METHODS The …

Purpose We aimed to develop a meropenem population pharmacokinetic (PK) model in
critically ill children and simulate dosing regimens in order to optimize patient exposure …