The foundations of research ethics are riven with fault lines emanating from a fear that if
research is too closely connected to weighty social purposes an imperative to advance the …

Background Early in the COVID-19 pandemic, the urgent need to discover effective
therapies for COVID-19 prompted questions about the ethical problem of randomization …

Is the concept of clinical equipoise still relevant to research? | The BMJ Skip to main content
Intended for healthcare professionals Access provided by Google Indexer Subscribe My …

The concept of clinical equipoise restricts the use of placebo controls in clinical trials when
there already exists a proven effective treatment. Several critics of clinical equipoise have …

The COVID-19 pandemic touched off an unprecedented search for vaccines and treatments.
Without question, the development of vaccines to prevent COVID-19 was an enormous …

Ethics has been identified as a central reason for choosing the stepped wedge trial over
other kinds of trial designs. The potential advantage of the stepped wedge design is that it …

Does the moral requirement that medical research comparing the effectiveness of two
treatment methods be done only when there is community level equipoise also apply to …

The fiduciary relationship is a legal relationship that describes those interactions in which
one party is entrusted to exercise discretionary power on behalf of another's significant …

Informed consent and equipoise are key components in the ethical analysis of clinical trials.
However, these concepts were developed during a time when “clinical trial” primarily …