The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

K Dheda, T Gumbo, G Maartens, KE Dooley… - The lancet Respiratory …, 2017 - thelancet.com
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management

D Liebenberg, BG Gordhan, BD Kana - Frontiers in cellular and …, 2022 - frontiersin.org
Drug resistant tuberculosis contributes significantly to the global burden of antimicrobial
resistance, often consuming a large proportion of the healthcare budget and associated …

High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial

MJ Boeree, N Heinrich, R Aarnoutse… - The Lancet infectious …, 2017 - thelancet.com
Background Tuberculosis is the world's leading infectious disease killer. We aimed to
identify shorter, safer drug regimens for the treatment of tuberculosis. Methods We did a …

Extreme drug tolerance of Mycobacterium tuberculosis in caseum

JP Sarathy, LE Via, D Weiner, L Blanc… - Antimicrobial agents …, 2018 - Am Soc Microbiol
Tuberculosis (TB) recently became the leading infectious cause of death in adults, while
attempts to shorten therapy have largely failed. Dormancy, persistence, and drug tolerance …

Update on tuberculosis biomarkers: from correlates of risk, to correlates of active disease and of cure from disease

D Goletti, MR Lee, JY Wang, N Walter… - …, 2018 - Wiley Online Library
Tuberculosis (TB) remains a devastating disease, yet despite its enormous toll on global
health, tools to control TB are insufficient and often outdated. TB Biomarkers (TB‐BM) would …

Bacterial and host determinants of cough aerosol culture positivity in patients with drug-resistant versus drug-susceptible tuberculosis

G Theron, J Limberis, R Venter, L Smith, E Pietersen… - Nature medicine, 2020 - nature.com
A burgeoning epidemic of drug-resistant tuberculosis (TB) threatens to derail global control
efforts. Although the mechanisms remain poorly clarified, drug-resistant strains are widely …

Tuberculosis bacteria detection and counting in fluorescence microscopy images using a multi-stage deep learning pipeline

M Zachariou, O Arandjelović, W Sabiiti, B Mtafya… - Information, 2022 - mdpi.com
The manual observation of sputum smears by fluorescence microscopy for the diagnosis
and treatment monitoring of patients with tuberculosis (TB) is a laborious and subjective …

Revolutionizing control strategies against Mycobacterium tuberculosis infection through selected targeting of lipid metabolism

H Kim, SJ Shin - Cellular and Molecular Life Sciences, 2023 - Springer
Lipid species play a critical role in the growth and virulence expression of Mycobacterium
tuberculosis (Mtb), the causative agent of tuberculosis (TB). During Mtb infection, foamy …

Defining dormancy in mycobacterial disease

S Lipworth, RJH Hammond, VO Baron, Y Hu, A Coates… - Tuberculosis, 2016 - Elsevier
Tuberculosis remains a threat to global health and recent attempts to shorten therapy have
not succeeded mainly due to cases of clinical relapse. This has focussed attention on the …

Assessment of treatment response in tuberculosis

N Rockwood, E du Bruyn, T Morris… - Expert review of …, 2016 - Taylor & Francis
Antibiotic treatment of tuberculosis has a duration of several months. There is significant
variability of the host immune response and the pharmacokinetic-pharmacodynamic …