Oxidative stress-induced endothelial dysfunction in cardiovascular diseases
Cardiovascular disease (CVD) is a major cause of mortality worldwide. A better
understanding of the mechanisms underlying CVD is key for better management or …
understanding of the mechanisms underlying CVD is key for better management or …
[HTML][HTML] Reactive oxygen species in inflammation and tissue injury
SM Rizwan, P ReddySekhar… - Antioxidants & redox …, 2014 - liebertpub.com
Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …
the progression of inflammatory disorders. An enhanced ROS generation by …
ROS signaling in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)
M Kellner, S Noonepalle, Q Lu, A Srivastava… - … redox signaling in …, 2017 - Springer
The generation of reactive oxygen species (ROS) plays an important role for the
maintenance of cellular processes and functions in the body. However, the excessive …
maintenance of cellular processes and functions in the body. However, the excessive …
Mitochondrial oxidative stress in aging and healthspan
The free radical theory of aging proposes that reactive oxygen species (ROS)-induced
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …
Cross talk between mitochondria and NADPH oxidases
S Dikalov - Free Radical Biology and Medicine, 2011 - Elsevier
Reactive oxygen species (ROS) play an important role in physiological and pathological
processes. In recent years, a feed-forward regulation of the ROS sources has been reported …
processes. In recent years, a feed-forward regulation of the ROS sources has been reported …
Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities
WI Sivitz, MA Yorek - Antioxidants & redox signaling, 2010 - liebertpub.com
Given their essential function in aerobic metabolism, mitochondria are intuitively of interest
in regard to the pathophysiology of diabetes. Qualitative, quantitative, and functional …
in regard to the pathophysiology of diabetes. Qualitative, quantitative, and functional …
[HTML][HTML] Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes
H Jin, A Kanthasamy, A Ghosh, V Anantharam… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Parkinson's disease is a progressive neurodegenerative disease in the elderly, and no cure
or disease-modifying therapies exist. Several lines of evidence suggest that mitochondrial …
or disease-modifying therapies exist. Several lines of evidence suggest that mitochondrial …
Animal and human studies with the mitochondria‐targeted antioxidant MitoQ
As mitochondrial oxidative damage contributes to a wide range of human diseases,
antioxidants designed to be accumulated by mitochondria in vivo have been developed. The …
antioxidants designed to be accumulated by mitochondria in vivo have been developed. The …
Subset-specific mitochondrial stress and DNA damage shape T cell responses to fever and inflammation
Heat is a cardinal feature of inflammation, yet its impacts on immune cells remain uncertain.
We show that moderate-grade fever temperatures (39° C) increased murine CD4 T cell …
We show that moderate-grade fever temperatures (39° C) increased murine CD4 T cell …
Mitochondria-targeted small molecule therapeutics and probes
Significance: Mitochondrial function is central to a wide range of biological processes in
health and disease and there is considerable interest in developing small molecules that are …
health and disease and there is considerable interest in developing small molecules that are …