Molecular mechanisms of action of novel psychoactive substances (NPS). A new threat for young drug users with forensic-toxicological implications
A Giorgetti, JP Pascali, P Fais, G Pelletti, A Gabbin… - Life, 2021 - mdpi.com
Novel psychoactive substances (NPS) represent a severe health risk for drug users. Even
though the phenomenon has been growing since the early 2000s, the mechanisms of action …
though the phenomenon has been growing since the early 2000s, the mechanisms of action …
Effects of synthetic cannabinoids on psychomotor, sensory and cognitive functions relevant for safe driving
Recreational use of Synthetic Cannabinoids (SCs), one of the largest groups of New
Psychoactive Substances (NPS), has increased globally over the past few years. Driving is a …
Psychoactive Substances (NPS), has increased globally over the past few years. Driving is a …
Varenicline enhances recognition memory via α7 nicotinic acetylcholine receptors in the medial prefrontal cortex in male mice
H Esaki, S Deyama, S Izumi, A Katsura, K Nishikawa… - …, 2023 - Elsevier
Previous studies postulated that chronic administration of varenicline, a partial and full
agonist at α4β2 and α7 nicotinic acetylcholine receptors (nAChRs), respectively, enhances …
agonist at α4β2 and α7 nicotinic acetylcholine receptors (nAChRs), respectively, enhances …
Nicotine enhances object recognition memory via stimulating α4β2 and α7 nicotinic acetylcholine receptors in the medial prefrontal cortex of mice
H Esaki, S Izumi, A Fukao, S Ito, N Nishitani… - Biological and …, 2021 - jstage.jst.go.jp
Nicotine has been known to enhance recognition memory in various species. However, the
brain region where nicotine acts and exerts its effect remains unclear. Since the medial …
brain region where nicotine acts and exerts its effect remains unclear. Since the medial …
[HTML][HTML] Intranasal administration of resolvin E1 produces antidepressant-like effects via BDNF/VEGF-mTORC1 signaling in the medial prefrontal cortex
Intracerebroventricular infusion of resolvin E1 (RvE1), a bioactive metabolite derived from
eicosapentaenoic acid, exerts antidepressant-like effects in a mouse model of …
eicosapentaenoic acid, exerts antidepressant-like effects in a mouse model of …
Role of 5-HT1A receptors in the basolateral amygdala on 3, 4-methylenedioxymethamphetamine-induced prosocial effects in mice
H Esaki, Y Sasaki, N Nishitani, H Kamada… - European Journal of …, 2023 - Elsevier
methylenedioxymethamphetamine (MDMA), a recreational drug, induces euphoric
sensations and psychosocial effects, such as increased sociability and empathy. Serotonin …
sensations and psychosocial effects, such as increased sociability and empathy. Serotonin …
Synthetic cannabinoid JWH-073 alters both acute behavior and in vivo/vitro electrophysiological responses in mice
M Barbieri, M Tirri, S Bilel, R Arfè, G Corli… - Frontiers in …, 2022 - frontiersin.org
JWH-073 is a synthetic cannabinoid (SCB) that is illegally marketed within an “herbal blend”,
causing psychoactive effects more intense than those produced by Cannabis. Users report …
causing psychoactive effects more intense than those produced by Cannabis. Users report …
MAM-2201 acute administration impairs motor, sensorimotor, prepulse inhibition, and memory functions in mice: a comparison with its analogue AM-2201
G Corli, M Tirri, S Bilel, R Arfè, T Coccini, E Roda… - …, 2023 - Springer
Abstract Rationale 1-[(5-fluoropentyl)-1 H-indol-3-yl](4-methyl-1-naphthalenyl) methanone
(MAM-2201) is a potent synthetic cannabinoid receptor agonist illegally marketed in “spice” …
(MAM-2201) is a potent synthetic cannabinoid receptor agonist illegally marketed in “spice” …
The antidepressant-like effect of resolvin E1 in repeated prednisolone-induced depression model mice
S Aoki, S Deyama, R Sugie, K Ishimura… - Behavioural Brain …, 2022 - Elsevier
Abstract Resolvin E1 (RvE1) is an anti-inflammatory lipid mediator derived from
eicosapentaenoic acid. We previously demonstrated that intracerebroventricular (icv) and …
eicosapentaenoic acid. We previously demonstrated that intracerebroventricular (icv) and …
The synthetic CB1 cannabinoid receptor selective agonists: Putative medical uses and their legalization
A Coronado-Álvarez, K Romero-Cordero… - Progress in Neuro …, 2021 - Elsevier
More than 500 molecules have been identified as components of Cannabis sativa (C.
sativa), of which the most studied is Δ 9-tetrahydrocannabinol (Δ 9-THC). Several studies …
sativa), of which the most studied is Δ 9-tetrahydrocannabinol (Δ 9-THC). Several studies …