Transcriptional regulation is essential for the correct functioning of cells during development
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …

Neurogenesis persists in adult mammals in specific brain areas, known as neurogenic
niches. Adult neurogenesis is highly dynamic and is modulated by multiple physiological …

The emergence of the three germ layers and the lineage-specific precursor cells
orchestrating organogenesis represent fundamental milestones during early embryonic …

The thymus' key function in the immune system is to provide the necessary environment for
the development of diverse and self-tolerant T lymphocytes. While recent evidence suggests …

Radial glial (RG) development is essential for cerebral cortex growth and organization. In
humans, the outer radial glia (oRG) subtype is expanded and gives rise to diverse neurons …

Abstract Analysis of chromatin accessibility can reveal transcriptional regulatory sequences,
but heterogeneity of primary tissues poses a significant challenge in mapping the precise …

The basic helix-loop-helix transcription factors Ascl1/Mash1, Hes1, and Olig2 regulate fate
choice of neurons, astrocytes, and oligodendrocytes, respectively. These same factors are …

Glioblastomas exhibit a hierarchical cellular organization, suggesting that they are driven by
neoplastic stem cells that retain partial yet abnormal differentiation potential. Here, we show …

The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …

The identification of neurological symptoms caused by vitamin A deficiency pointed to a
critical, early developmental role of vitamin A and its metabolite, retinoic acid (RA). The …