Ocular drug delivery: a comprehensive review

S Ahmed, MM Amin, S Sayed - AAPS PharmSciTech, 2023 - Springer
The human eye is a sophisticated organ with distinctive anatomy and physiology that
hinders the passage of drugs into targeted ophthalmic sites. Effective topical administration …

Corneal targeted fenticonazole nitrate-loaded novasomes for the management of ocular candidiasis: Preparation, in vitro characterization, ex vivo and in vivo …

S Ahmed, MM Amin, SM El-Korany, S Sayed - Drug Delivery, 2022 - Taylor & Francis
The purpose of this manuscript was to develop and optimize Fenticonazole Nitrate (FTN)-
loaded novasomes aiming to enhance drug corneal penetration and to improve its …

Transdermal application of diacerin loaded-terpene enriched invasomes: an approach to augment anti-edema and nociception inhibition activity

S Ahmed, MM Farag, MA Sadek… - Journal of Liposome …, 2024 - Taylor & Francis
This study aimed to formulate diacerein loaded terpene-enriched invasomes (DCN-TINV) to
fulfill a fruitful management of osteoarthritis. A 23 factorial design was adopted, including A …

A comprehensive review on recent nanosystems for enhancing antifungal activity of fenticonazole nitrate from different routes of administration

S Ahmed, MM Amin, S Sayed - Drug Delivery, 2023 - Taylor & Francis
This review aims to comprehensively highlight the recent nanosystems enclosing
Fenticonazole nitrate (FTN) and to compare between them regarding preparation …

Self-assembling lecithin-based mixed polymeric micelles for nose to brain delivery of clozapine: In-vivo assessment of drug efficacy via radiobiological evaluation

FM Elsharkawy, MM Amin… - International Journal …, 2023 - Taylor & Francis
Purpose The research objective is to design intranasal brain targeted CLZ loaded lecithin
based polymeric micelles (CLZ-LbPM) aiming to improve central systemic CLZ …

Magnetic targeting of lornoxicam/SPION bilosomes loaded in a thermosensitive in situ hydrogel system for the management of osteoarthritis: Optimization, in vitro, ex …

B Ibrahiem, R Shamma, A Salama, H Refai - Drug Delivery and …, 2024 - Springer
Osteoarthritis is a bone and joint condition characterized pathologically by articular cartilage
degenerative damage and can develop into a devastating and permanently disabling …

Emu oil enriched nanostructured lipid carriers of lornoxicam burdened polymeric gel augmented drug delivery and assisted cartilage repairing in knee osteoarthritis: In …

A Bhosale, VGSS Jyothi, P Devangan, G Bajad… - Journal of Drug Delivery …, 2024 - Elsevier
Lornoxicam (LRX) alleviates pain and inflammation associated with knee osteoarthritis
(OAS). However, inadequate solubility, short half-life, and gastrointestinal side-effects on …

Brain targeting efficiency of intranasal clozapine-loaded mixed micelles following radio labeling with Technetium-99m

S Sayed, FM Elsharkawy, MM Amin… - Drug Delivery, 2021 - Taylor & Francis
The research objective is to design intranasal (IN) brain targeted CLZ-loaded polymeric
nanomicellar systems (PNMS) aiming to improve central systemic CLZ bioavailability. Direct …

Optimization and characterization of sodium alginate beads providing extended release for antidiabetic drugs

B Sipos, M Benei, G Katona, I Csóka - Molecules, 2023 - mdpi.com
The current research is aimed at investigating the relationship between the formulation
components and conditions in the case of a binary drug delivery system, where antidiabetic …

Pronounced capping effect of olaminosomes as nanostructured platforms in ocular candidiasis management

S Ahmed, MM Amin, SM El-Korany, S Sayed - Drug Delivery, 2022 - Taylor & Francis
The aim of this study was to formulate and boost ocular targeting of Fenticonazole Nitrate
(FTN)-loaded olaminosomes in order to improve drug corneal permeation and candidiasis …