Isatins as privileged molecules in design and synthesis of spiro-fused cyclic frameworks

GS Singh, ZY Desta - Chemical Reviews, 2012 - ACS Publications
1. INTRODUCTION Indoline-2, 3-dione or indole-1H-2, 3-dione (Figure 1), commonly known
as isatin, is a well-known natural product found in plants of genus Isatis and in Couropita …

Biochemical and pharmacological characterization of isatin and its derivatives: from structure to activity

P Pakravan, S Kashanian, MM Khodaei… - Pharmacological …, 2013 - Springer
Abstract Isatin, k1H-indole-2, 3-dione, kis a heterocyclic compound of significant importance
in medicinal chemistry. It is a synthetically versatile molecule, ka precursor for a large …

Asymmetric catalysis for the synthesis of spirocyclic compounds

AK Franz, NV Hanhan, NR Ball-Jones - ACS Catalysis, 2013 - ACS Publications
Spirocycles provide an exciting platform to develop and understand the reactivity and
selectivity for a wide variety of catalysts while affording diverse strategies to access …

One-pot tandem approach to spirocyclic oxindoles featuring adjacent spiro-stereocenters.

YL Liu, X Wang, YL Zhao, F Zhu… - Angewandte …, 2013 - search.ebscohost.com
All in a sequence: An organocatalyzed Morita–Baylis–Hillman (MBH)/bromination/[3+ 2]
annulation sequence for highly stereoselective syntheses of bis (spirooxindole) s featuring …

Pyridine activation via copper (I)-catalyzed annulation toward indolizines

J Barluenga, G Lonzi, L Riesgo… - Journal of the …, 2010 - ACS Publications
The copper (I)-catalyzed regioselective [3+ 2] cyclization of pyridines toward
alkenyldiazoacetates leading to functionalized indolizine derivatives is reported. A broad …

Tertiary amine-catalyzed chemoselective and asymmetric [3+ 2] annulation of morita–baylis–hillman carbonates of isatins with propargyl sulfones

J Peng, X Huang, L Jiang, HL Cui, YC Chen - Organic Letters, 2011 - ACS Publications
A chemo-and enantioselective [3+ 2] annulation of Morita–Baylis–Hillman carbonates of
isatins with propargyl sulfones was catalyzed by a β-ICD O-MOM ether 1c, affording …

[4 + 3] Cycloadditions with Bromo-Substituted Morita–Baylis–Hillman Adducts of Isatins and N-(ortho-Chloromethyl)aryl Amides

G Zhan, ML Shi, Q He, W Du, YC Chen - Organic letters, 2015 - ACS Publications
Efficient construction of a challenging aza-spirocycloheptane oxindole scaffold is reported
through an unprecedented [4+ 3] cycloaddition reaction with bromo-substituted Morita …

Recent progress on routes to spirooxindole systems derived from isatin

M Xia, RZ Ma - Journal of Heterocyclic Chemistry, 2014 - Wiley Online Library
Because of their definite or potential biological and pharmaceutical activities, spirooxindole
heterocycles have been widely studied, and there has occurred a research boom on routes …

Palladium-catalyzed approach to the synthesis of five-membered O-heterocycles

N Kaur - Inorganic Chemistry Communications, 2014 - Elsevier
In recent decades, a large number of reports related to the synthesis of N, O and S
containing heterocycles have appeared owing to a wide variety of their biological activity …

Highly enantioselective [3+ 2]-annulation of isatin-derived morita–baylis–hillman adducts with cyclic sulfonimines

F Wei, HY Huang, NJ Zhong, CL Gu, D Wang… - Organic letters, 2015 - ACS Publications
An organocatalytic [3+ 2]-annulation between isatin-derived Morita–Baylis–Hillman adducts
and cyclic sulfonimines has been developed in high yields with excellent enantio-and …