Cell polarity refers to the orientation of tissue and organelles within a cell and the direction of
its function. It is one of the most critical characteristics of metazoans. The development …

The Gleason score is the gold standard for grading of prostate cancer (PCa) and is
assessed by assigning specific grades to different microscopical growth patterns. Aside from …

Polycystic kidney disease (PKD) is a common genetic disorder arising from developmental
and postnatal processes. Defects in primary cilia and their signaling (eg, mTOR) underlie the …

Epidermal growth factor (EGF) has important effects in the renal collecting duct to regulate
salt and water transport. To identify elements of EGF-mediated signaling in the rat renal …

Diseases affecting the glomerulus, the filtration unit of the kidney, are a major cause of
chronic kidney disease. Glomerular disease is characterised by injury of glomerular cells …

Autosomal dominant polycystic kidney disease (ADPKD), a congenital genetic disorder, is a
notable contributor to the prevalence of chronic kidney disease worldwide. Despite the …

Plasma ultrafiltration in the kidney occurs across glomerular capillaries, which are
surrounded by epithelial cells called podocytes. Podocytes have a unique shape maintained …

In metazoans, cells collectively polarize and align along the tissue plane. This phenomenon
is called Planar cell polarity (PCP). Polarization means asymmetric segregation of …

Introduction: Focal segmental glomerulosclerosis (FSGS) is a significant cause of chronic
kidney disease and triggered by podocyte damage which can result in cytoskeletal …

Planar cell polarity (PCP)–asymmetric localization of proteins at cell-cell interface–is
essential for embryonic development and physiological functions. Abnormalities in PCP can …