Liver regeneration: biological and pathological mechanisms and implications
GK Michalopoulos, B Bhushan - Nature reviews Gastroenterology & …, 2021 - nature.com
The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-
to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid …
to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid …
Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities
Macrophages, which are key cellular components of the liver, have emerged as essential
players in the maintenance of hepatic homeostasis and in injury and repair processes in …
players in the maintenance of hepatic homeostasis and in injury and repair processes in …
Liver regeneration and inflammation: from fundamental science to clinical applications
Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …
Liver homeostasis is maintained by midlobular zone 2 hepatocytes
INTRODUCTION The liver's remarkable capacity to maintain proper tissue mass after injury
has been known since ancient times. However, there has been considerable debate about …
has been known since ancient times. However, there has been considerable debate about …
Long-term expansion of functional mouse and human hepatocytes as 3D organoids
The mammalian liver possesses a remarkable regenerative ability. Two modes of damage
response have been described:(1) The" oval cell" response emanates from the biliary tree …
response have been described:(1) The" oval cell" response emanates from the biliary tree …
Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair
L He, W Pu, X Liu, Z Zhang, M Han, YI Li, X Huang… - Science, 2021 - science.org
INTRODUCTION Cell proliferation is a fundamental process in all multicellular organisms
that is required to enable development, tissue homeostasis, tissue repair, and tissue …
that is required to enable development, tissue homeostasis, tissue repair, and tissue …
Spatial heterogeneity in the mammalian liver
S Ben-Moshe, S Itzkovitz - Nature reviews Gastroenterology & …, 2019 - nature.com
Hepatocytes operate in highly structured repeating anatomical units termed liver lobules.
Blood flow along the lobule radial axis creates gradients of oxygen, nutrients and hormones …
Blood flow along the lobule radial axis creates gradients of oxygen, nutrients and hormones …
Liver cancer cell of origin, molecular class, and effects on patient prognosis
Primary liver cancer is the second leading cause of cancer-related death worldwide and
therefore a major public health challenge. We review hypotheses of the cell of origin of liver …
therefore a major public health challenge. We review hypotheses of the cell of origin of liver …
Single-cell spatial reconstruction reveals global division of labour in the mammalian liver
KB Halpern, R Shenhav, O Matcovitch-Natan, B Toth… - Nature, 2017 - nature.com
The mammalian liver consists of hexagon-shaped lobules that are radially polarized by
blood flow and morphogens,,,. Key liver genes have been shown to be differentially …
blood flow and morphogens,,,. Key liver genes have been shown to be differentially …
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
The role of adaptive immunity in early cancer development is controversial. Here we show
that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver …
that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver …