Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

Skeletal muscle plays a critical role in physical function and metabolic health. Muscle is a
highly adaptable tissue that responds to resistance exercise (RE; loading) by …

The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

Skeletal muscle force production is increased at longer compared to shorter muscle lengths
because of length-dependent priming of thick filament proteins in the contractile unit before …

Myc is a powerful transcription factor implicated in epigenetic reprogramming, cellular
plasticity, and rapid growth as well as tumorigenesis. Cancer in skeletal muscle is extremely …

The discovery of the giant protein titin, also known as connectin, dates almost half a century
back. In this review, I recapitulate major advances in the discovery of the titin filaments and …

Skeletal muscle is one of the tissues with the highest ability to regenerate, a finely controlled
process which is critically depending on muscle stem cells. Muscle stem cell functionality …

During natural aging, skeletal muscle experiences impairments in mechanical performance
due, in part, to changes in muscle architecture and size, notably with a loss of muscle cross …

Muscle specific signaling has been shown to originate from myofilaments and their
associated cellular structures, including the sarcomeres, costameres or the cardiac …

Striated muscle responds to mechanical overload by rapidly up-regulating the expression of
the cardiac ankyrin repeat protein, CARP, which then targets the sarcomere by binding to …