Protein S-nitrosylation constitutes a large part of the ubiquitous influence of nitric oxide on
cellular signal transduction and accumulating evidence indicates important roles for S …

Epidemiological and clinical studies have linked exposure to particulate matter (PM) to
adverse health effects, which may be registered as increased mortality and morbidity from …

Multipotent mesenchymal stromal cells (MSCs) ameliorate a wide range of diseases in
preclinical models, but the lack of clarity around their mechanisms of action has impeded …

It is established that the adipocyte-derived cytokine adiponectin protects against
cardiovascular and metabolic diseases, but the effect of this adipokine on macrophage …

Group 2 innate lymphoid cells (ILC2s) regulate tissue inflammation and repair after
activation by cell-extrinsic factors such as host-derived cytokines. However, the cell-intrinsic …

Despite IL-9 functioning as a pleiotropic cytokine in mucosal environments, the IL-9–
responsive cell repertoire is still not well defined. Here, we found that IL-9 mediates …

Asthma is a heterogeneous disease with many phenotypes, and age at disease onset is an
important factor in separating the phenotypes. Most studies with asthma have been …

Chronic asthma is an inflammatory airways disease characterized by pathological changes
in the airway smooth muscle (ASM) bundle that contribute to airway obstruction and …

Asthma is considered a Th2 cell–associated disorder. Despite this, both the Th1 cell–
associated cytokine IFN-γ and airway neutrophilia have been implicated in severe asthma …

Obesity is an asthma comorbidity associated with poor control, increased exacerbation risk
and reduced response to inhaled and systemic corticosteroids. It affects children and adults …