Nature, in its wonders, presents and assembles the most intricate and delicate protein
structures and this remarkable phenomenon occurs in all kingdom and phyla of life. Of these …

Several nanoparticle platforms are currently being developed for applications in medicine,
including both synthetic materials and naturally occurring bionanomaterials such as viral …

As synthetic pathways built from exogenous enzymes become more complicated, the
probability of encountering undesired interactions with host organisms increases, thereby …

In recent years, a myriad of intravenously administrated nanoparticle (NP)-based drug
delivery systems such as liposomes,[1] micelles,[2] and albumin nanoparticles [3] have been …

Observing and visualizing objects, with the help of tools, which cannot be seen with the
naked eye, had always raised curiosity among the scientific community and given scientific …

Therapeutic proteins can face substantial challenges to their activity, requiring protein
modification or use of a delivery vehicle. Nanoparticles can significantly enhance delivery of …

Highlights•Stability and built-in weaknesses are emergent properties of adenovirus particles
and key for gene delivery.•Entry is a gain of function process where the virion uncoats in a …

Background Based on our preclinical findings, we are assessing the efficacy of intratumoral
injection of dendritic cells (DC) transduced with an adenoviral vector expressing the …

Recently, the potential use of nanoparticles for the targeted delivery of therapeutic and
diagnostic agents has garnered increased interest. Several nanoparticle drug delivery …

The identification of the adenovirus (AdV) protein that mediates endosome penetration
during infection has remained elusive. Several lines of evidence from previous studies …