Multiciliated cells (MCC) project dozens to hundreds of motile cilia from the cell surface to
generate fluid flow across epithelial surfaces or turbulence to promote the transport of …

Sensorineural hearing loss is the most prevalent sensory deficit in humans. Most cases of
hearing loss are due to the degeneration of key structures of the sensory pathway in the …

Adult neural stem cells and multiciliated ependymal cells are glial cells essential for
neurological functions. Together, they make up the adult neurogenic niche. Using both high …

The molecular mechanisms that maintain cellular identities and prevent dedifferentiation or
transdifferentiation remain mysterious. However, both processes are transiently used during …

Background Axis patterning during development is accompanied by large-scale gene
expression changes. These are brought about by changes in the histone modifications …

Most of the cranial sense organs of vertebrates arise from embryonic structures known as
cranial placodes. Such placodes also give rise to sensory neurons that transmit information …

In this study, we aimed to identify the tumor suppressive roles of zinc finger of the cerebellum
1 (ZIC1) in patients with malignant breast neoplasms and to examine the association …

Introduction Neural induction of human induced pluripotent stem cells represents a critical
switch in cell state during which pluripotency is lost and commitment to a neural lineage is …

Covalent histone modifications play an essential role in gene regulation and cellular
specification required for multicellular organism development. Monoubiquitination of histone …

Proper functions of Zic proteins are essential for animals in health and disease. Here, we
summarize our current understanding of the molecular properties and functions of the Zic …