Prostate cancer (PCa) is a prevalent malignancy that occurs primarily in old males. Prostate
tumors in different patients manifest significant inter-patient heterogeneity with respect to …

Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

Bioinformatic analysis of 94 patient-derived xenografts (PDXs), cell lines, and organoids
(PCOs) identifies three intrinsic transcriptional subtypes of metastatic castration-resistant …

Background Castration‐insensitive epithelial progenitors capable of regenerating the
prostate have been proposed to be concentrated in the proximal region based on facultative …

In the era of precision medicine, the identification of new targets is a constant challenge to
improve cancer therapy. Preclinical investigations, epidemiological studies and analyses of …

Prostate cancer (PCa) has a predominantly luminal phenotype. Basal cells were previously
identified as a cell of origin for PCa, but increasing evidence implicates luminal cells as a …

Stem and progenitor cells of the adult prostate epithelium have historically been believed to
reside mainly or exclusively within the basal cell compartment and to possess basal-like …

Recent developments in pre-clinical screening tools, that more reliably predict the clinical
effects and adverse events of candidate therapeutic agents, has ushered in a new era of …

Advanced prostate malignancies are a leading cause of cancer-related deaths in men, in
large part due to our incomplete understanding of cellular drivers of disease progression …

Epidemiological data have linked vitamin D deficiency to the onset and severity of various
cancers, including prostate cancer, and although in vitro studies have demonstrated …