Autophagy is an essential cellular mechanism which plays “housekeeping” role in normal
physiological processes including removing of long lived, aggregated and misfolded …

Mitophagy is a vital form of autophagy for selective removal of dysfunctional or redundant
mitochondria. Accumulating evidence implicates elimination of dysfunctional mitochondria …

Biological aging is an inevitable and independent risk factor for a wide array of chronic
diseases including cardiovascular and metabolic diseases. Ample evidence has established …

Sequestosome1 (p62/SQSTM 1) is a multidomain protein that interacts with the autophagy
machinery as a key adaptor of target cargo. It interacts with phagophores through the LC3 …

Nix is a membrane‐anchored outer mitochondrial protein that induces mitophagy. While Nix
has an LC3‐interacting (LIR) motif that binds to ATG8 proteins, it also contains a minimal …

Autophagy is a catabolic process involving vacuolar sequestration of intracellular
components and their targeting to lysosomes for degradation, thus supporting nutrient …

Mitochondria undergo continuous challenges in the course of their life, from their generation
to their degradation. These challenges include the management of reactive oxygen species …

Mammalian autophagy-related protein Atg8, including the LC3 subfamily and GABARAP
subfamily. Atg8 proteins play a vital role in autophagy initiation, autophagosome formation …

Macroautophagy (hereafter referred to as autophagy) is an intracellular degradative
process, well conserved among eukaryotes. By engulfing cytoplasmic constituents into the …

Macroautophagy/autophagy has emerged as a central process in lymphocyte homeostasis,
activation and differentiation. Based on our finding that the p66 isoform of SHC1 (p66SHC) …