Background: Engineering cardiac tissue that mimics the hierarchical structure of cardiac
tissue remains challenging, raising the need for developing novel methods capable of …

Extracellular matrix (ECM) collagen density and fibril anisotropy are thought to affect the
development of new vasculatures during pathologic and homeostatic angiogenesis …

Biological tissues and biomaterials routinely feature a fibrous microstructure that contributes
to physical and mechanical properties while influencing cellular guidance, organization and …

Regenerative biomaterials are commonly used for soft-tissue repair in both pre-clinical and
clinical settings, but their effectiveness is often limited by poor regenerative outcomes and …

Understanding and controlling of the evolution of sprouting vascular networks remains one
of the basic challenges in tissue engineering. Previous studies on the vascularization …

Angiogenesis, the formation of new blood vessels, is a fundamental process in both
physiological repair mechanisms and pathological conditions, including cancer and chronic …

BACKGROUND: Microvascular fragment (MVF) isolates are generated by short-term
enzymatic digestion of adipose tissue and contain numerous vessel segments for the …

Purpose The primary aim of this study was to develop an open-source Python-based
software for the automated analysis of dynamic cell behaviors in microphysiological models …

The formation of new vascular networks via angiogenesis is a crucial biological mechanism
to balance tissue metabolic needs, yet the coordination of factors that influence the guidance …

Cell migration is a complex process ubiquitously observed across both physiologic
development and disease progression. The phenotype by which cells migrate includes both …