Per-and polyfluoroalkyl substances (PFAS) are a class of synthetic chemicals colloquially
known as “forever chemicals” because of their high persistence. PFAS have been detected …

Gut health is determined by an intact epithelial barrier and balanced gut microbiota, both
involved in the regulation of immune responses in the gut. Disruption of this system …

Gastric cancer (GC) is the fifth most commonly diagnosed malignancy. Paclitaxel (PTX) is an
effective first-line chemotherapy drug in GC treatment, but the resistance of PTX attenuates …

Adenosine triphosphate-binding cassette (ABC) transporters, including P-glycoprotein (Pgp)
and multi-resistance associated proteins (Mrps), have been considered important …

Abstract The European Commission asked EFSA to update its 2011 risk assessment on
hexabromocyclododecanes (HBCDD s) in food. HBCDD s, predominantly mixtures of the …

We review the evidence regarding the nongenomic (or non-canonical) actions of thyroid
hormones (thyronines) and their derivatives (including thyronamines and thyroacetic acids) …

Per-and polyfluoroalkyl (PFAS) substances are a type of chemical compound unique for
their multiple carbon-fluorine bonds, imbuing them with strength and environmental …

Small molecule transporters (SMTs) in the ABC and SLC families are important players in
disposition of diverse endo‐and xenobiotics. Interactions of environmental chemicals with …

Environmental health science seeks to predict how environmental toxins, chemical toxicants,
and prescription drugs accumulate and interact within the body. Xenobiotic transporters of …

The resistance of cancer to chemotherapeutic agents is a major obstacle during
chemotherapy. Clinical multidrug resistance (MDR) is commonly mediated by membrane …