EMT: Mechanisms and therapeutic implications
Metastasis, the dissemination of cancer cells from primary tumors, represents a major hurdle
in the treatment of cancer. The epithelial-mesenchymal transition (EMT) has been studied in …
in the treatment of cancer. The epithelial-mesenchymal transition (EMT) has been studied in …
A role for partial epithelial-to-mesenchymal transition in enabling stemness in homeostasis and cancer
J Verstappe, G Berx - Seminars in Cancer Biology, 2023 - Elsevier
Stem cells have self-renewal capacities and the ability to give rise to differentiated cells
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …
Optimal-transport analysis of single-cell gene expression identifies developmental trajectories in reprogramming
Understanding the molecular programs that guide differentiation during development is a
major challenge. Here, we introduce Waddington-OT, an approach for studying …
major challenge. Here, we introduce Waddington-OT, an approach for studying …
Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci
Summary RNA polymerase II (RNAPII) pausing in early elongation is critical for gene
regulation. Paused RNAPII can be released into productive elongation by the kinase P-TEFb …
regulation. Paused RNAPII can be released into productive elongation by the kinase P-TEFb …
Construction of a cross-species cell landscape at single-cell level
Individual cells are basic units of life. Despite extensive efforts to characterize the cellular
heterogeneity of different organisms, cross-species comparisons of landscape dynamics …
heterogeneity of different organisms, cross-species comparisons of landscape dynamics …
Cooperative binding of transcription factors orchestrates reprogramming
Summary Oct4, Sox2, Klf4, and cMyc (OSKM) reprogram somatic cells to pluripotency. To
gain a mechanistic understanding of their function, we mapped OSKM-binding, stage …
gain a mechanistic understanding of their function, we mapped OSKM-binding, stage …
Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade
L Li, K Chen, T Wang, Y Wu, G Xing, M Chen… - Nature …, 2020 - nature.com
Somatic cell reprogramming provides insight into basic principles of cell fate determination,
which remain poorly understood. Here we show that the transcription factor Glis1 induces …
which remain poorly understood. Here we show that the transcription factor Glis1 induces …
Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE
J He, IA Babarinde, L Sun, S Xu, R Chen, J Shi… - Nature …, 2021 - nature.com
Transposable elements (TEs) make up a majority of a typical eukaryote's genome, and
contribute to cell heterogeneity in unclear ways. Single-cell sequencing technologies are …
contribute to cell heterogeneity in unclear ways. Single-cell sequencing technologies are …
Systematic identification of cell-fate regulatory programs using a single-cell atlas of mouse development
Waddington's epigenetic landscape is a metaphor frequently used to illustrate cell
differentiation. Recent advances in single-cell genomics are altering our understanding of …
differentiation. Recent advances in single-cell genomics are altering our understanding of …
Chromatin accessibility dynamics during iPSC reprogramming
Cell-fate decisions remain poorly understood at the chromatin level. Here, we map
chromatin remodeling dynamics during induction of pluripotent stem cells. ATAC-seq …
chromatin remodeling dynamics during induction of pluripotent stem cells. ATAC-seq …