Evolutionary constraint and innovation across hundreds of placental mammals

MJ Christmas, IM Kaplow, DP Genereux, MX Dong… - Science, 2023 - science.org
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

Anatomical, ontogenetic, and genomic homologies guide reconstructions of the teeth-to-baleen transition in mysticete whales

J Gatesy, EG Ekdale, TA Deméré, A Lanzetti… - Journal of Mammalian …, 2022 - Springer
Abstract The transition in Mysticeti (Cetacea) from capture of individual prey using teeth to
bulk filtering batches of small prey using baleen ranks among the most dramatic …

Gene loss may have shaped the cnidarian and bilaterian Hox and ParaHox complement

BM Steinworth, MQ Martindale… - Genome Biology and …, 2023 - academic.oup.com
Hox and ParaHox transcription factors are important for specifying cell fates along the
primary body axes during the development of most animals. Within Cnidaria, much of the …

Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow

D Le Duc, A Velluva, M Cassatt-Johnstone… - Science …, 2022 - science.org
Steller's sea cow, an extinct sirenian and one of the largest Quaternary mammals, was
described by Georg Steller in 1741 and eradicated by humans within 27 years. Here, we …

Gene duplications and gene loss in the epidermal differentiation complex during the evolutionary land-to-water transition of cetaceans

KB Holthaus, J Lachner, B Ebner, E Tschachler… - Scientific Reports, 2021 - nature.com
Major protein components of the mammalian skin barrier are encoded by genes clustered in
the Epidermal Differentiation Complex (EDC). The skin of cetaceans, ie whales, porpoises …

Gene losses may contribute to subterranean adaptations in naked mole-rat and blind mole-rat

Z Zheng, R Hua, G Xu, H Yang, P Shi - BMC biology, 2022 - Springer
Abstract Background Naked mole-rats (Heterocephalus glaber, NMRs) and blind mole-rats
(Spalax galili, BMRs) are representative subterranean rodents that have evolved many …

Defining Wound Healing Progression in Cetacean Skin: Characteristics of Full-Thickness Wound Healing in Fraser's Dolphins (Lagenodelphis hosei)

CY Su, MW Hughes, TY Liu, CM Chuong, HV Wang… - Animals, 2022 - mdpi.com
Simple Summary Cutaneous wound healing is a complex and tightly regulated biological
process to restore physiological and anatomic function. Current knowledge of cutaneous …

Genomic and anatomical comparisons of skin support independent adaptation to life in water by cetaceans and hippos

MS Springer, CF Guerrero-Juarez, M Huelsmann… - Current Biology, 2021 - cell.com
The macroevolutionary transition from terra firma to obligatory inhabitance of the marine
hydrosphere has occurred twice in the history of Mammalia: Cetacea and Sirenia. In the …

Sirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder afrotheria

R Tian, Y Zhang, H Kang, F Zhang, Z Jin… - Nature …, 2024 - nature.com
Sirenians of the superorder Afrotheria were the first mammals to transition from land to water
and are the only herbivorous marine mammals. Here, we generated a chromosome-level …

Comparative genomics of sirenians reveals evolution of filaggrin and caspase-14 upon adaptation of the epidermis to aquatic life

J Steinbinder, AP Sachslehner, KB Holthaus… - Scientific Reports, 2024 - nature.com
The mammalian epidermis has evolved to protect the body in a dry environment. Genes of
the epidermal differentiation complex (EDC), such as FLG (filaggrin), are implicated in the …