Rheumatoid arthritis is an autoimmune disease that primarily affects the joints. The
emergence of highly effective anti-rheumatic drugs such as biologic agents and janus …

Peptidylarginine deiminases (PADs) are calcium-dependent enzymes that mediate
citrullination, an irreversible post-translational modification (PTM). PAD enzymes have …

Hidradenitis suppurativa (HS), also known as acne inversa, is an incapacitating skin
disorder of unknown etiology manifested as abscess-like nodules and boils resulting in …

Rheumatoid arthritis (RA) is a chronic autoimmune disorder that causes joint inflammation
and damage. Extra-articular manifestations occur in many patients and can include lung …

In recent years, a possible association of lifestyle factors with rheumatoid arthritis (RA) has
attracted increasing public interest. The aim of this review is to provide an overview of the …

Objectives Events in the lungs might contribute to generation of anticitrullinated protein
antibodies (ACPA) in rheumatoid arthritis (RA). We investigated if signs of immune activation …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that is
characterized by synovial hyperplasia and progressive joint destruction. The activation of RA …

Rheumatoid arthritis (RA) is caused by prolonged periodic interactions between genetic,
environmental, and immunologic factors. Posttranslational modifications (PTMs) such as …

Citrullination, the conversion of peptidyl-arginine into peptidyl-citrulline, is involved in the
breakage of self-tolerance in anti-CCP-positive rheumatoid arthritis. This reaction is …

Cartilage has a limited healing capacity; however, studies into the basic biological
characteristics, formation and structural maintenance of the cartilage collagen network are …