T cell lineages are defined by specialized functions and differential expression of surface
antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the …

As interest in γδ T cells grows rapidly, what key points are emerging, and where is caution
warranted? γδ T cells fulfill critical functions, as reflected in associations with vaccine …

Metabolic programming controls immune cell lineages and functions, but little is known
about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ …

The anatomic location and immunologic characteristics of brain tumors result in strong
lymphocyte suppression. Consequently, conventional immunotherapies targeting CD8 T …

Developmental thymic waves of innate-like and adaptive-like γδ T cells have been
described, but the current understanding of γδ T cell development is mainly limited to mouse …

T lymphocytes expressing γδ T cell antigen receptors (TCRs) comprise evolutionarily
conserved cells with paradoxical features. On the one hand, clonally expanded γδ T cells …

γδ T cells are an abundant T cell population at the mucosa and are important in providing
immune surveillance as well as maintaining tissue homeostasis. However, despite γδ T …

Epithelial and mucosal barriers are critical interfaces physically separating the body from the
outside environment and are the tissues most exposed to microorganisms and potential …

γδ T cells are the first T cell lineage to develop in the thymus and take up residence in a
wide variety of tissues where they can provide fast, innate-like sources of effector cytokines …

Unconventional T cells include γδ T cells, invariant Natural Killer T cells (iNKT) cells and
Mucosal Associated Invariant T (MAIT) cells, which are distinguished from conventional T …